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Review
. 2023 Nov;9(11):2358-2387.
doi: 10.1016/j.jacep.2023.06.005. Epub 2023 Aug 16.

Cardiac Conduction System Pacing: A Comprehensive Update

Pugazhendhi Vijayaraman  1 , Mihal G Chelu  2 , Karol Curila  3 , Gopi Dandamudi  4 , Bengt Herweg  5 , Shumpei Mori  6 , Marek Jastrzebski  7 , Parikshit S Sharma  8 , Kalyanam Shivkumar  6 , Roderick Tung  9 , Gaurav Upadhyay  10 , Kevin Vernooy  11 , Allan Welter-Frost  12 , Zachary Whinnett  13 , Francesco Zanon  14 , Kenneth A Ellenbogen  15
Affiliations
Free article
Review

Cardiac Conduction System Pacing: A Comprehensive Update

Pugazhendhi Vijayaraman et al. JACC Clin Electrophysiol. 2023 Nov.
Free article

Abstract

The field of cardiac pacing has changed rapidly in the last several years. Since the initial description of His bundle pacing targeting the conduction system, recent advances in pacing the left bundle branch and its fascicles have evolved. The field and investigators' knowledge of conduction system pacing including relevant anatomy and physiology has advanced significantly. The aim of this review is to provide a comprehensive update on recent advances in conduction system pacing.

Keywords: His bundle pacing; cardiac resynchronization therapy; clinical trials; conduction system pacing; left bundle branch pacing.

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Conflict of interest statement

Funding Support and Author Disclosures Work on anatomy was made possible by support from National Institutes of Health grants OT2OD023848 (to Dr K Shivkumar) and from the Tawara-McAlpine Festschrift (a component of the UCLA Amara-Yad Project). Dr Vijayaraman has received honoraria, consulting fees, and research and fellowship support from Medtronic; honoraria from Biotronik and Boston Scientific; and consulting fees from Abbott; and holds a patent for an HBP delivery tool. Dr Chelu has received research support from PCORI, National Institutes of Health, Abbott, and Impulse Dynamics; and honoraria from Impulse Dynamics. Dr Curila has received consulting fees and honoraria from Medtronic, Biotronik, and Abbott; has filed U.S. patent: US11,517,243B2: “Method of electrocardiographic signal processing and apparatus for performing the method”; and is a shareholder of VDI Technologies. Dr Dandamudi has received honoraria and consulting fees from Medtronic; and served on advisory boards of Medtronic, Biotronik, and Abbott. Dr Herweg has served as a speaker and consultant for Abbott; and has received speaking fees and fellowship support from Medtronic. Dr Jastrzebski has received honoraria and consulting fees from Medtronic and Abbott. Dr Sharma has received honoraria from Medtronic; and consulting fees from Medtronic, Abbott, Biotronik, and Boston Scientific. Dr Shivkumar is a cofounder of NeuCures Inc. Dr Tung has received honoraria and consulting fees from– Abbott. Dr Upadhyay has received honoraria from and served on advisory boards for Abbott, Biotronik, Boston Scientific, Medtronic, Philips BioTel, and Zoll Medical. Dr Vernooy has received consulting fees from Biosense Webster, Philips, Medtronic, and Abbott; honoraria from Microport; and research and educational grants (paid to institution) from Philips, Abbott, Medtronic, and Biosense Webster. Dr Whinnett has received honoraria from Medtronic and Boston Scientific; and consulting fees from Medtronic and Abbott. Dr Zanon has received honoraria from Abbott, Biotronik, Boston Scientific, Medtronic, and Microport. Dr Ellenbogen has received consulting fees from Medtronic, Boston Scientific, Abbott, and Biotronik; and honoraria from Medtronic, Boston Scientific, and Biotronik. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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