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Comment
. 2023 Aug 29;120(35):e2312196120.
doi: 10.1073/pnas.2312196120. Epub 2023 Aug 17.

Toward building a library of cell type-specific drivers across developmental stages

Cheng Lyu #  1   2 , Zhuoran Li #  1   2 , Liqun Luo  1   2
Affiliations
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Toward building a library of cell type-specific drivers across developmental stages

Cheng Lyu et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
An approach to generate cell type–specific drivers throughout different life stages of the fly. Top row: the life cycle of a fly begins with an egg that develops into the stage of larvae, pupae, young adult, and aged adult. Second row: scRNAseq datasets from various tissues or brain regions could provide the related gene expression profiles across life stages. Left to right, fly ovary, optic lobes, antennae and antennal lobes, ventral nerve cord, midgut, head, and body. Third and bottom rows: if two genes are both expressed only in one or a few transcriptomic clusters (corresponding to cell types) across multiple life stages, the genetic intersection of this gene pair could lead to cell type–specific drivers across life stages. Hypothetical transcriptomic clusters from only one life stage are shown. As an example, Chen et al. show consistent labeling of a cell type–specific driver in the developing and adult Drosophila optic lobe. (Scale bar: 10 µm.) P15, P50: time when pupal development reaches 15% and 50%, respectively. Images are adapted from Chen et al. (6).
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References

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