Comment
doi: 10.1016/j.neuron.2023.07.014.
Spinocerebellar ataxia type 1: It's not just about Purkinje cells
Affiliations
- PMID: 37591199
- DOI: 10.1016/j.neuron.2023.07.014
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Comment
Spinocerebellar ataxia type 1: It's not just about Purkinje cells
Neuron.
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Abstract
In this issue of Neuron, Pilotto et al.1 use state-of-the-art in vivo imaging in mice to show that excitatory/inhibitory imbalance drives SCA1 pathophysiology, with hyperexcitable molecular layer interneurons overinhibiting Purkinje cells, leading to hallmark neurodegeneration.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1.Neuron. 2023 Aug 16;111(16):2523-2543.e10. doi: 10.1016/j.neuron.2023.05.016. Epub 2023 Jun 14. Neuron. 2023. PMID: 37321222 Free PMC article.