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. 2023 Sep:53:102703.
doi: 10.1016/j.nano.2023.102703. Epub 2023 Aug 15.

Ruthenium metallodendrimer against triple-negative breast cancer in mice

Sylwia Michlewska  1 , Dagmara Wójkowska  2 , Cezary Watala  2 , Elżbieta Skiba  3 , Paula Ortega  4 , Francisco Javier de la Mata  4 , Maria Bryszewska  5 , Maksim Ionov  5
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Free article

Ruthenium metallodendrimer against triple-negative breast cancer in mice

Sylwia Michlewska et al. Nanomedicine. 2023 Sep.
Free article

Abstract

Carbosilane metallodendrimers, based on the arene Ru(II) complex (CRD13) and integrated to imino-pyridine surface groups have been investigated as an anticancer agent in a mouse model with triple-negative breast cancer. The dendrimer entered into the cells efficiently, and exhibited selective toxicity for 4T1 cells. In vivo investigations proved that a local injection of CRD13 caused a reduction of tumour mass and was non-toxic. ICP analyses indicated that Ru(II) accumulated in all tested tissues with a greater content detected in the tumour.

Keywords: Anticancer agent; In vivo; Ruthenium metallodendrimer; Toxicity; Tumour weight.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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