Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2023 Aug 17;23(1):241.
doi: 10.1186/s12893-023-02148-7.

Safety and efficacy of precision hepatectomy in the treatment of primary liver cancer

Junhong Zhang  1 , Pengfei Zhang  1 , Jinglin Cao  2
Affiliations
Randomized Controlled Trial

Safety and efficacy of precision hepatectomy in the treatment of primary liver cancer

Junhong Zhang et al. BMC Surg. .

Abstract

Background: The aim of this study was to investigate the safety and efficacy of precision hepatectomy in the treatment of primary liver cancer.

Methods: An randomized controlled trial of 98 patients with primary liver cancer admitted to our hospital from February 2020 to February 2021 were analyzed for the study, and they were divided into 49 cases each in the control group (conventional hepatectomy) and the study group (precision hepatectomy) according to the different surgical methods. The surgical condition, complications and follow-up results of the two groups were counted, and the liver function and immune function of the two groups were observed before and 1 week after surgery.

Results: The operation time, intraoperative bleeding, hospitalization time and anal venting time in the study group were less than those in the control group (P < 0.05). One week after surgery, AST, TBiL, ALT and ALB levels decreased, with in the study group significantly higher than those in the control group (P < 0.05); CD4+, CD3 + and CD4+/CD8 + levels were significantly higher in the study group (P < 0.05). The incidence of complications in the study group was significantly lower than that in the control group (P < 0.05). After 2 years of follow-up, the recurrence rate and mortality rate of the study group were lower than those of the control group (P < 0.05); the difference was not statistically significant when comparing the metastasis rate between the two groups (P > 0.05).

Conclusion: Precision hepatectomy can effectively treat primary liver cancer with high safety and could be promoted in clinical practice.

Keywords: Conventional hepatectomy; Precision hepatectomy; Primary liver cancer.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Similar articles

See all similar articles

Cited by

References

    1. Bosch FX, Ribes J, Díaz M, et al. Primary liver cancer: worldwide incidence and trends. Gastroenterology. 2004;127(5):5–S16. doi: 10.1053/j.gastro.2004.09.011. - DOI - PubMed
    1. Petrick JL, McGlynn KA. The changing epidemiology of primary liver cancer. Curr Epidemiol Rep. 2019;6:104–11. doi: 10.1007/s40471-019-00188-3. - DOI - PMC - PubMed
    1. Satriano L, Lewinska M, Rodrigues PM, et al. Metabolic rearrangements in primary liver cancers: cause and consequences. Nat reviews Gastroenterol Hepatol. 2019;16(12):748–66. doi: 10.1038/s41575-019-0217-8. - DOI - PubMed
    1. Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition) Liver cancer. 2020;9(6):682–720. doi: 10.1159/000509424. - DOI - PMC - PubMed
    1. Lurje I, Czigany Z, Bednarsch J, et al. Treatment strategies for hepatocellular carcinoma—a multidisciplinary approach. Int J Mol Sci. 2019;20(6):1465. doi: 10.3390/ijms20061465. - DOI - PMC - PubMed

Publication types