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. 2023 Nov 11;228(10):1311-1313.
doi: 10.1093/infdis/jiad353.

SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds

Ninaad Lasrado  1 , Dan H Barouch  1   2
Affiliations

SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds

Ninaad Lasrado et al. J Infect Dis. .

Abstract

Three and a half years into the coronavirus disease 2019 (COVID-19) pandemic, the nature and durability of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still remains unclear. Current COVID-19 mRNA vaccines have been shown to provide minimal protection against infection with XBB variants but substantial protection against severe disease. However, such protection appears to wane quickly. In contrast, protection from the combination of both vaccination and infection, termed "hybrid immunity", has been shown to be greater in magnitude and durability than that provided by either vaccine immunity or natural immunity alone.

Keywords: COVID-19; SARS-CoV-2; T cells; hybrid immunity; mRNA vaccines; neutralizing antibodies.

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Conflict of interest statement

Potential conflicts of interest. D. H. B. is a co-inventor on provisional vaccine patents (63/121 482; 63/133 969; 63/135 182). N. L. reports no conflicts of interest. Both authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.