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. 2023 Aug 1:14:1209616.
doi: 10.3389/fphar.2023.1209616. eCollection 2023.

Neurotoxicology of alcohol: a bibliometric and science mapping analysis

Paulo Fernando Santos Mendes  1 , Daiane Claydes Baia-da-Silva  1 , Wallacy Watson Pereira Melo  1 , Leonardo Oliveira Bittencourt  1 , Renata Duarte Souza-Rodrigues  1 , Luanna Melo Pereira Fernandes  2 , Cristiane do Socorro Ferraz Maia  1 , Rafael Rodrigues Lima  1
Affiliations

Neurotoxicology of alcohol: a bibliometric and science mapping analysis

Paulo Fernando Santos Mendes et al. Front Pharmacol. .

Abstract

Alcohol consumption is common in many societies and has increased considerably, resulting in many socioeconomic and public health problems. In this sense, studies have been carried out in order to understand the mechanisms involved in alcohol consumption and related harmful effects. This study aimed to identify and map the knowledge and to perform bibliometric analysis of the neurotoxicology of alcohol based on the 100 most cited articles. A search was carried out in the Web of Science Core Collection database and information was extracted regarding the journal, authors, keywords, year of publication, number of citations, country and continent of the corresponding author. For each selected manuscript, the study design, alcohol exposure model, dose, period of exposure, and effect on the central nervous system and research hotspots were mapped. The journal with the highest number of publications was Alcoholism: Clinical and Experimental Research (n = 11 papers), the author who contributed the most was Crews FT (n = 8 papers), the studies had a total of 288 keywords and 75% of the publications were from the United States of America. The experimental studies evaluated the effects of prenatal and postnatal exposure and were conducted in rats and mice using doses ranging from 2.5 to 14 g/kg/day, with administration by subcutaneous, intraperitoneal, intragastric, or inhalation route or with free access through drinking bottles. Among the studies mapped, the oldest one (1989) aimed to understand the systemic damage and mechanisms of action involved, while the most recent focused on understanding the receptors and mechanisms involved in addiction, as well as genetic factors. Our results show the panorama of the most widespread scientific production in the scientific community on the neurotoxicology of ethanol, a high prevalence was observed in studies that addressed fetal alcohol syndrome and/or the effects of ethanol on neurodevelopment.

Keywords: alcohol; alcohol abuse; alcoholism; bibliometric; central nervous system.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Mechanisms of alcohol-induced nervous system damage.
FIGURE 2
FIGURE 2
Flowchart of the literature search and article screening.
FIGURE 3
FIGURE 3
Publications and number of citations each year of the top 100 articles related to use of alcohol and central nervous system effects.
FIGURE 4
FIGURE 4
Journals with at least two published articles.
FIGURE 5
FIGURE 5
Network visualization of co-authorship: (A) The largest set of connected authors (n = 72 authors); (B) All authors with at least one papers (n = 371authors), showing the authors with the largest number of articles published about the neurotoxicology of alcohol. The node size represents the number of documents: the larger the node, the greater the number of articles. Clusters are represented by different colors and the lines indicate co-citation links between authors.
FIGURE 6
FIGURE 6
Overlay visualization of co-occurrence of author-keywords with a no minimum of two occurrences. Clusters are represented by different colors and the lines indicate co-citation links between keywords.
FIGURE 7
FIGURE 7
Geographical distribution of the corresponding authors of the 100 most cited articles on the neurotoxicology of alcohol.
See this image and copyright information in PMC

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References

    1. Ahmad S. J. S., Ahmed A. R., Kowalewski K. F., Nickel F., Rostami K., Stocker C. J., et al. (2020). Citation classics in general medical journals: Assessing the quality of evidence; A systematic review. Gastroenterol Hepatol Bed Bench 13 (2), 101–114. - PMC - PubMed
    1. Alfonso-Loeches S., Pascual-Lucas M., Blanco A. M., Sanchez-Vera I., Guerri C. (2010). Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. J. Neurosci. 30 (24), 8285–8295. 10.1523/JNEUROSCI.0976-10.2010 - DOI - PMC - PubMed
    1. Astley S. J., Clarren S. K. (2000). Diagnosing the full spectrum of fetal alcohol-exposed individuals: Introducing the 4-digit diagnostic code. Alcohol Alcohol 35 (4), 400–410. 10.1093/alcalc/35.4.400 - DOI - PubMed
    1. Bakkalbasi N., Bauer K., Glover J., Wang L. (2006). Three options for citation tracking: Google scholar, Scopus and Web of science. Biomed. Digit. Libr. 3, 7–8. 10.1186/1742-5581-3-7 - DOI - PMC - PubMed
    1. Bava S., Tapert S. F. (2010). Adolescent brain development and the risk for alcohol and other drug problems. Neuropsychol. Rev. 20 (4), 398–413. 10.1007/s11065-010-9146-6 - DOI - PMC - PubMed

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