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Comment
. 2023 Aug 17;83(16):2834-2836.
doi: 10.1016/j.molcel.2023.07.025.

Lifting the curtain on loop extrusion barriers: Single-molecule insights into cohesin stalling

Luca Braccioli  1 , Elzo de Wit  2
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Comment

Lifting the curtain on loop extrusion barriers: Single-molecule insights into cohesin stalling

Luca Braccioli et al. Mol Cell. .
Free article

Abstract

In this issue, Zhang et al.1 show that CTCF blocks cohesin-mediated loop extrusion in an orientation-dependent manner. Using single-molecule imaging assays, the authors find that dCas9 and R-loops can also stall extrusion.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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