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Comment
. 2023 Sep 11;41(9):1548-1550.
doi: 10.1016/j.ccell.2023.07.008. Epub 2023 Aug 17.

Deciphering the landscape of transcriptional heterogeneity across cancer

Thomas P Jones  1 , Nicholas McGranahan  2
Affiliations
Free article
Comment

Deciphering the landscape of transcriptional heterogeneity across cancer

Thomas P Jones et al. Cancer Cell. .
Free article

Abstract

By integrating scRNA-seq datasets across 77 studies and 24 cancer types, in Nature, Gavish et al. uncover recurrent patterns of gene expression that explain a significant proportion of transcriptomic heterogeneity observed in cancer and explore their functional significance.

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Conflict of interest statement

Declaration of interests N.M. has received consultancy fees and has stock options in Achilles Therapeutics. N.M. holds European patents relating to targeting neoantigens (PCT/EP2016/059,401), identifying patient response to immune checkpoint blockade (PCT/EP2016/071,471), determining HLA LOH (PCT/GB2018/052,004), and predicting survival rates of patients with cancer (PCT/GB2020/050,221).

Comment on

  • Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours.
    Gavish A, Tyler M, Greenwald AC, Hoefflin R, Simkin D, Tschernichovsky R, Galili Darnell N, Somech E, Barbolin C, Antman T, Kovarsky D, Barrett T, Gonzalez Castro LN, Halder D, Chanoch-Myers R, Laffy J, Mints M, Wider A, Tal R, Spitzer A, Hara T, Raitses-Gurevich M, Stossel C, Golan T, Tirosh A, Suvà ML, Puram SV, Tirosh I. Gavish A, et al. Nature. 2023 Jun;618(7965):598-606. doi: 10.1038/s41586-023-06130-4. Epub 2023 May 31. Nature. 2023. PMID: 37258682

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