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. 2023 Oct;33(10):1255-1258.
doi: 10.1089/thy.2023.0236. Epub 2023 Sep 13.

The Relationship Between Fetal THRB Genotype and Maternal Thyroid Function

Affiliations

The Relationship Between Fetal THRB Genotype and Maternal Thyroid Function

Federico Salas-Lucia et al. Thyroid. 2023 Oct.
No abstract available

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Conflict of interest statement

No competing financial interests exist.

Figures

FIG. 1.
FIG. 1.
Maternal TFTs throughout pregnancy. Serum TSH levels for AfMo (A) and NlMo (C) as a function of gestational age. The best-fitted line and the CIs bandwidth are included. Histograms for mean TSH levels for AfMo (B) and NlMo (D). Values before pregnancy (week 0) and pools for 8-week intervals from weeks 1 to 40. (E) Serum fT4 and (H) serum fT3 levels as a function of gestational age for AFMo and NlMo. Histograms for the mean fT4 values for AFMo (F) and NLMo (G). Histograms for the mean fT3 values for AFMo (I) and NLMo (J). Values are mean ± SEM: *p < 0.05, ***p < 0.001. AfFe, affected fetus; AfMo, affected mother; CI, 95% confidence interval; fT3, free triiodothyronine; fT4, free thyroxine; NlFe, normal fetus; NlMo, normal mother; SEM, standard error of the mean; TFTs, thyroid function tests; TSH, thyrotropin; ULN, the upper limit of normal as 100%.

References

    1. Pappa T, Refetoff S. Resistance to thyroid hormone beta: A focused review. Front Endocrinol (Lausanne) 2021;12:656551; doi: 10.3389/fendo.2021.656551 - DOI - PMC - PubMed
    1. Anselmo J, Cao D, Karrison T, et al. . Fetal loss associated with excess thyroid hormone exposure. JAMA 2004;292(6):691–695; doi: 10.1001/jama.292.6.691 - DOI - PubMed
    1. Salas-Lucia F, Stan MN, James H, et al. . Effect of the fetal THRB genotype on the placenta. J Clin Endocrinol Metab 2023; doi: 10.1210/clinem/dgad243 - DOI - PMC - PubMed
    1. Moran C, Chatterjee K. Maternal resistance to thyroid hormone β and pregnancy outcomes. J Clin Endocrinol Metab 2023; doi: 10.1210/clinem/dgad350 - DOI - PMC - PubMed
    1. Srichomkwun P, Anselmo J, Liao XH, et al. . Fetal exposure to high maternal thyroid hormone levels causes central resistance to thyroid hormone in adult humans and mice. J Clin Endocrinol Metab 2017;102(9):3234–3240; doi: 10.1210/jc.2017-00019 - DOI - PMC - PubMed

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