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Published Erratum
. 2023 Aug 19;22(1):139.
doi: 10.1186/s12943-023-01842-7.

Correction: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Tao Zhang #  1 , Rong Qu #  1 , Shingpan Chan #  2 , Mengzhen Lai  1   3 , Linjiang Tong  1 , Fang Feng  1 , Hongyu Chen  4 , Tingting Song  4 , Peiran Song  1 , Gang Bai  1   5   6 , Yingqiang Liu  1   3 , Yanan Wang  1 , Yan Li  1 , Yi Su  1 , Yanyan Shen  1 , Yiming Sun  1 , Yi Chen  1 , Meiyu Geng  1 , Ke Ding  7 , Jian Ding  8 , Hua Xie  9
Affiliations
Published Erratum

Correction: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Tao Zhang et al. Mol Cancer. .
No abstract available

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Figures

Fig. 5
Fig. 5
Activation of antiapoptotic signaling through the Ack1/AKT pathway contributes to ASK120067 resistance. a The levels of AKT phosphorylation (p-AKT) in NCI-H1975 and 67R cells were determined by immunoblotting analysis. b The inhibitory activity of ASK120067 on p-AKT expression in NCIH1975 cells and 67R cells was compared. c Knockdown of Ack1 expression using short hairpin RNA (shRNA) decreased the levels of phosphorylated AKT in 67R cells. d The mRNA and protein levels of proapoptotic protein BIM in NCI-H1975 and 67R cells were determined by real-time PCR (left panel) and Western blot analysis (right panel), respectively. e The effect of ASK120067 on BIM expression in NCI-H1975 and 67R cells was examined. f Knockdown of Ack1 expression in 67R cells increased the expression of BIM by decreasing the phosphorylation of AKT. g to i, the combination of ASK120067 with Ack1 inhibitors synergistically suppressed AKT activation g and induced the transcription h and protein expression of BIM i
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Erratum for

References

    1. Zhang T, Qu R, Chan S, et al. Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance. Mol Cancer. 2020;19:90. doi: 10.1186/s12943-020-01202-9. - DOI - PMC - PubMed

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