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Review
. 2023 Oct:166:115324.
doi: 10.1016/j.biopha.2023.115324. Epub 2023 Aug 18.

TET protein inhibitors: Potential and limitations

Robert Kaplánek  1 , Zdeněk Kejík  1 , Jan Hajduch  1 , Kateřina Veselá  1 , Kateřina Kučnirová  1 , Markéta Skaličková  1 , Anna Venhauerová  1 , Božena Hosnedlová  1 , Róbert Hromádka  1 , Petr Dytrych  2 , Petr Novotný  1 , Nikita Abramenko  1 , Veronika Antonyová  1 , David Hoskovec  2 , Petr Babula  3 , Michal Masařík  4 , Pavel Martásek  5 , Milan Jakubek  6
Affiliations
Free article
Review

TET protein inhibitors: Potential and limitations

Robert Kaplánek et al. Biomed Pharmacother. 2023 Oct.
Free article

Abstract

TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. Regulation of their activity by specific inhibitors could represent a promising therapeutic strategy. Therefore, this review describes various types of TET protein inhibitors in terms of their inhibitory mechanism and possible applicability. The potential and possible limitations of this approach are thoroughly discussed in the context of TET protein functionality in living systems. Furthermore, possible therapeutic strategies based on the inhibition of TET proteins are presented and evaluated, especially in the field of oncological diseases.

Keywords: Cancer; Inhibitor; Mitochondria; TET protein; Therapy.

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Conflict of interest statement

Declaration of Competing Interest Robert Kaplánek has no conflict of interest. Zdeněk Kejík has no conflict of interest. Jan Hajduch has no conflict of interest. Kateřina Veselá and Kateřina Kučnirová has no conflict of interest. Markéta Skaličková and Anna Venhauerová has no conflict of interest. Božena Hosnedlová has no conflict of interest. Róbert Hromádka has no conflict of interest. Petr Dytrych has no conflict of interest. Petr Novotný has no conflict of interest. Nikita Abramenko has no conflict of interest. Veronika Antonyová has no conflict of interest. David Hoshovec have no conflict of interest. Petr Babula has no conflict of interest. Michal Masařík has no conflict of interest. Pavel Martásek has no conflict of interest. Milan Jakubek has no conflict of interest.

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