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Review
. 2024 Feb;47(1):100655.
doi: 10.1016/j.bj.2023.100655. Epub 2023 Aug 19.

Nod-like receptors in inflammatory arthritis

Sahib Singh Madahar  1 , Alita Gideon  2 , Ali A Abdul-Sater  3
Affiliations
Review

Nod-like receptors in inflammatory arthritis

Sahib Singh Madahar et al. Biomed J. 2024 Feb.

Abstract

Nod-like receptors (NLRs) are innate immune receptors that play a key role in sensing components from pathogens and from damaged cells or organelles. NLRs form signaling complexes that can lead to activation of transcription factors or effector caspases - by means of inflammasome activation -Inflammatory arthritis (IA) culminating in promoting inflammation. An increasing body of research supports the role of NLRs in driving pathogenesis of IA, a collection of diseases that include rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis, and pediatric arthritis. In this review, we briefly discuss the main drivers of IA diseases and dive into the evidence for - and against - various NLRs in driving these diseases. We also review the studies examining the use of NLR and inflammasome inhibitors as potential therapies for IA.

Keywords: Ankylosing spondylitis; Gout; Nod-like receptors; Pediatric arthritis; Psoriatic arthritis; Rheumatoid arthritis.

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Conflict of interest statement

Conflicts of interest The authors have declared that no competing interests exist.

Figures

Fig. 1
Fig. 1
Contributions of NOD-like receptors (NLRs)to Inflammatory arthritis (IA). Several NLR family members contribute to the pathogenesis and development of IA. Polymorphisms in these NLR proteins have also been shown to be associated with risk to various IA diseases. Studies have also investigated inhibitors and other compounds (synthetic, natural and dietary) to validate the role of NLRs in driving these diseases and as potential therapies. Figure was created withBioRender.com.
See this image and copyright information in PMC

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