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. 1979 Jun;53(6):1191-6.

A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase

S J Weiss, J Turk, P Needleman
  • PMID: 376000
Free article

A mechanism for the hydroperoxide-mediated inactivation of prostacyclin synthetase

S J Weiss et al. Blood. 1979 Jun.
Free article

Abstract

Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical may be important in the modulation of prostacyclin synthesis in diseased states.

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