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Review
. 2023 Aug 3:15:1224633.
doi: 10.3389/fnagi.2023.1224633. eCollection 2023.

Research progress of mitophagy in chronic cerebral ischemia

Mayue Yu #  1   2 , Manqing Zhang #  3 , Peijie Fu  1   2 , Moxin Wu  1   2 , Xiaoping Yin  1   2 , Zhiying Chen  1   2
Affiliations
Review

Research progress of mitophagy in chronic cerebral ischemia

Mayue Yu et al. Front Aging Neurosci. .

Abstract

Chronic cerebral ischemia (CCI), a condition that can result in headaches, dizziness, cognitive decline, and stroke, is caused by a sustained decrease in cerebral blood flow. Statistics show that 70% of patients with CCI are aged > 80 years and approximately 30% are 45-50 years. The incidence of CCI tends to be lower, and treatment for CCI is urgent. Studies have confirmed that CCI can activate the corresponding mechanisms that lead to mitochondrial dysfunction, which, in turn, can induce mitophagy to maintain mitochondrial homeostasis. Simultaneously, mitochondrial dysfunction can aggravate the insufficient energy supply to cells and various diseases caused by CCI. Regulation of mitophagy has become a promising therapeutic target for the treatment of CCI. This article reviews the latest progress in the important role of mitophagy in CCI and discusses the induction pathways of mitophagy in CCI, including ATP synthesis disorder, oxidative stress injury, induction of reactive oxygen species, and Ca2+ homeostasis disorder, as well as the role of drugs in CCI by regulating mitophagy.

Keywords: chronic cerebral ischemia; mitochondrial autophagy; oxidative stress; stroke; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Molecules causing mitochondrial autophagy after CCI and regulatory protective targets.
FIGURE 2
FIGURE 2
Mitochondrial autophagy pathway in CCI.
See this image and copyright information in PMC

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