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. 2023 May 30:38:11-13.
doi: 10.1016/j.jdcr.2023.05.025. eCollection 2023 Aug.

Did dupilumab unmask smoldering mycosis fungoides?

Michelle Toker  1 , Pooja Srivastava  1   2 , Bijal Amin  1   2 , Benedict Wu  1
Affiliations

Did dupilumab unmask smoldering mycosis fungoides?

Michelle Toker et al. JAAD Case Rep. .
No abstract available

Keywords: atopic dermatitis; autoeczema; cutaneous T-cell lymphomas; dupilumab; eczema; id reaction; mycosis fungoides; radiation oncology.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Clinical images and histology from the initial visit. Scaly brown-violaceous plaques in a reticulated pattern on the (A) back, (B) left forearm, (C) chest and abdomen, and (D) left shoulder. E, Hematoxylin and eosin–stained section (original magnification: ×200) showing spongiosis and a perivascular and interstitial infiltrate containing lymphocytes, histiocytes, and many eosinophils.
Fig 2
Fig 2
During dupilumab treatment. Clinical images depicting significant improvement of prior eczema but now presenting with new hypopigmented ovoid patches and plaques on the (A) back, (B) left arm, (C) chest and abdomen, and (D) posterior aspect of the left shoulder.
Fig 3
Fig 3
Biopsy sites revealing mycosis fungoides in areas that were previously obscured by the autoeczema on the (A) posterior aspect of the scalp, (B) chest, and (C) back. D, Hematoxylin and eosin–stained section (original magnification: ×200) showing psoriasiform epidermal hyperplasia with atypical lymphocytes within the dermis and epidermis (epidermotropism). E, Immunohistochemistry (original magnification: ×100) showing diffuse expression of CD30 in the atypical lymphoid cells.
Fig 4
Fig 4
Flow diagrams illustrating patient timeline and theory of autoeczema masking mycosis fungoides (MF).
See this image and copyright information in PMC

References

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