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Review
. 2023 Jul 12:14:1180221.
doi: 10.3389/fimmu.2023.1180221. eCollection 2023.

Immunologic and nonimmunologic sclerodermal skin conditions - review

Carmen Bobeica  1 , Elena Niculet  1   2 , Mihaela Craescu  1   2 , Elena-Laura Parapiru  3 , Andreea Mioara Corduneanu-Luca  4 , Mihaela Debita  3 , Ana Maria Pelin  5 , Carmen Tiutiuca  6 , Claudiu Ionut Vasile  3 , Alin Codrut Nicolescu  7 , Magdalena Miulescu  1 , Gabriela Balan  3   8 , Alin Laurentiu Tatu  2   3   9
Affiliations
Review

Immunologic and nonimmunologic sclerodermal skin conditions - review

Carmen Bobeica et al. Front Immunol. .

Abstract

Scleroderma-like cutaneous lesions have been found in many pathological conditions and they have the clinical appearance of sclerotic or scleroatrophic lesions. Affected skin biopsies described histopathological changes similar to those of scleroderma located strictly on the skin or those of systemic sclerosis. These skin lesions can be found in inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host disease, eosinophilic fasciitis), tissue storage diseases (scleredema, scleromyxedema, nephrogenyc systemic fibrosis, systemic amyloidosis), metabolic diseases (porphyrya cutanea tarda, phenylketonuria, hypothyroidism, scleredema diabeticorum), progeroid syndromes. Given the multiple etiologies of sclerodermal lesions, a correct differential diagnosis is necessary to establish the appropriate treatment.

Keywords: immunological skin conditions; lichen sclerosus (balanitis xerotica obliterans); scleredema Burschke; scleroatrophic lichen; scleromyxedema; systemic sclerosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The pathogenic process of SSc - vasculopathy and fibrosis.
Figure 2
Figure 2
Sclerodactyly.
Figure 3
Figure 3
Scleroderma-like changes with thickened deep dermis collagen bundles and chronic inflammation.
Figure 4
Figure 4
The pathogenesis of morphea.
See this image and copyright information in PMC

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