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. 2023 Aug 15:13:45-53.
doi: 10.2147/DNND.S421399. eCollection 2023.

Risk of Obstructive Sleep Apnea in Saudi Male Boys with Duchenne Muscular Dystrophy (DMD)

Affiliations

Risk of Obstructive Sleep Apnea in Saudi Male Boys with Duchenne Muscular Dystrophy (DMD)

Ahmed Bamaga et al. Degener Neurol Neuromuscul Dis. .

Abstract

Background: Duchenne muscular dystrophy (DMD) patients are at a high risk of developing sleep-related breathing disorders (SRBD) such as obstructive sleep apnea (OSA). This study aimed to determine the risk of developing OSA among DMD patients.

Methods: This cross-sectional study was conducted from February 2022 to July 2022 in a tertiary healthcare facility. As a screening tool for OSA, we used the Pediatric Sleep Questionnaire (PSQ).

Results: Subjects included 60 boys with DMD, mean age 10.15 ± 3.54 years. The mean BMI for all subjects was 18.9 ± 4.08 kg/m2. Of these, 22 (36.7%) children were at high risk of OSA. Children who were overweight, and on steroids tended to be at higher risk of developing OSA (P < 0.043) and (P < 0.029) respectively.

Conclusion: Our study shows a significant risk of OSA in DMD patients. Therefore, Sleep studies should be part of the standard of care for DMD patients.

Keywords: Duchenne muscular dystrophy; Saudi Arabia; obstructive sleep apnea; pediatric sleep questionnaire.

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Conflict of interest statement

The authors have no conflict of interest to report.

Figures

Figure 1
Figure 1
Pediatric Sleep Questionnaire (PSQ) in English and Arabic versions.
Figure 2
Figure 2
Weight status category of patients with or without OSA.
Figure 3
Figure 3
Age category of patients with or without OSA.

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References

    1. Bello L, Pegoraro E. The “usual suspects”: genes for inflammation, fibrosis, regeneration, and muscle strength modify Duchenne muscular dystrophy. J Clin Med. 2019;8(5):649. doi:10.3390/jcm8050649 - DOI - PMC - PubMed
    1. Emery AE. Population frequencies of inherited neuromuscular diseases—a world survey. Neuromuscular Disorders. 1991;1(1):19–29. doi:10.1016/0960-8966(91)90039-U - DOI - PubMed
    1. Bradley D, Parsons E. Newborn screening for Duchenne muscular dystrophy. Semin Neonatol. 1998;3(1):27–34. doi:10.1016/S1084-2756(98)80146-2 - DOI - PubMed
    1. Blake DJ, Weir A, Newey SE, Davies KE. Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev. 2002;82(2):291–329. doi:10.1152/physrev.00028.2001 - DOI - PubMed
    1. Barbe F, Quera-Salva MA, McCann C, et al. Sleep-related respiratory disturbances in patients with Duchenne muscular dystrophy. Eur Respir J. 1994;7(8):1403–1408. doi:10.1183/09031936.94.07081403 - DOI - PubMed