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Review
. 2023 Jan-Mar;19(1):87-98.
doi: 10.4183/aeb.2023.87. Epub 2023 Aug 14.

ADIPONECTIN LEVELS IN GRAVES' DISEASE - SYSTEMATIC REVIEW AND META-ANALYSIS

A Ismaiel  1 , A L Abunahleh  2 , A Elsayed  3 , D C Leucuţa  4 , S L Popa  1 , M Ismaiel  5 , D L Dumitrascu  1
Affiliations
Review

ADIPONECTIN LEVELS IN GRAVES' DISEASE - SYSTEMATIC REVIEW AND META-ANALYSIS

A Ismaiel et al. Acta Endocrinol (Buchar). 2023 Jan-Mar.

Abstract

Context: Graves' disease is the most prevalent cause of hyperthyroidism worldwide. Adiponectin, the most abundant adipokine, plays a significant role in a cluster of prevalent diseases connected to metabolic disorders.

Objective: Although the association between adiponectin and Graves' disease has been studied, the existing data is inconsistent. Therefore, we conducted this systematic review and meta-analysis to evaluate the relationship between adiponectin levels and Graves' disease.

Methods: We performed a systematic electronic search on PubMed, EMBASE, Scopus and Cochrane Library using predefined keywords. We used the NHLBI quality assessment tools to assess the included studies.

Results: There were 11 studies involving 781 subjects included in our qualitative synthesis, while 6 studies were included in our quantitative synthesis. We observed significantly increased adiponectin levels in Graves' disease patients compared to controls (MD 2.983 [95% CI 0.138-5.828]) and hypothyroidism patients (MD 3.389 [95% CI 1.332-5.446]). Nevertheless, no significant MD was observed when comparing Graves' disease patients with and without Graves' ophthalmopathy (MD -27.124 [95% CI -88.893 - 34.645]).

Conclusions: Adiponectin levels were significantly higher in patients with Graves' disease compared to controls and hypothyroidism patients. However, patients with and without Graves' ophthalmopathy did not present a significant mean difference in adiponectin levels.

Keywords: Graves' disease; adipokines; adiponectin; endocrinology; hyperthyroidism.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram summarizing the identification, screening and inclusion phases of our systematic review and meta-analysis.
Figure 2
Figure 2
Adiponectin levels in Graves' disease vs. controls.
Figure 3
Figure 3
Adiponectin levels in Graves' disease vs. hypothyroidism.
Figure 4
Figure 4
Adiponectin levels in Graves' disease patients with and without Graves' ophthalmopathy.
See this image and copyright information in PMC

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