Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors in Heart Failure: An Umbrella Review
- PMID: 37602002
- PMCID: PMC10436676
- DOI: 10.7759/cureus.42113
Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors in Heart Failure: An Umbrella Review
Abstract
Heart failure remains a leading cause of hospitalization and death, and presents a significant challenge for healthcare providers despite the advancements in its management. This umbrella review aimed to pool the results of meta-analyses on the use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors in the treatment of heart failure patients. A literature search was done on five databases: PubMed, Cochrane Library, Scopus, Global Index Medicus, and Science Direct for articles with full texts available online. Meta-analyses of five or more randomized controlled trials (RCTs) were included; the assessment of multiple systematic reviews (AMSTAR) was used to assess the quality of included studies. A systematic search identified 10 relevant meta-analyses of RCTs, with primary analyses including outcome data from 171,556 heart failure patients. A pooled review showed that SGLT-2 inhibitors significantly reduced the risk of heart failure hospitalization, cardiovascular death, mortality, serious adverse events, and improved quality of life. SGLT-2 inhibitors are likely safe and effective in managing patients with heart failure especially considering the acute outcomes.
Keywords: cardiology research; heart failure hospitalization; heart failure prognosis; sglt2 inhibitors and heart failure; sodium-glucose cotransporter-2 (sglt-2) inhibitors.
Copyright © 2023, Roy et al.
Conflict of interest statement
The authors have declared that no competing interests exist.
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References
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- Heart disease and stroke statistics—2022 update: a report from the American Heart Association. Tsao CW, Aday AW, Almarzooq ZI, et al. Circulation. 2022;145:0–639. - PubMed
-
- Angiotensin-neprilysin inhibition versus enalapril in heart failure. McMurray JJ, Packer M, Desai AS, et al. N Engl J Med. 2014;371:993–1004. - PubMed
-
- Heart failure hospitalization with SGLT-2 inhibitors: a systematic review and meta-analysis of randomized controlled and observational studies. Singh AK, Singh R. Expert Rev Clin Pharmacol. 2019;12:299–308. - PubMed
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