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Case Reports
. 2023 Jul 19;15(7):e42122.
doi: 10.7759/cureus.42122. eCollection 2023 Jul.

Cranial Juvenile Psammomatoid Ossifying Fibroma: A Rare Entity

Muhammad Tahir  1 , Zan Ahmed  1 , Osama Elkadi  1
Affiliations
Case Reports

Cranial Juvenile Psammomatoid Ossifying Fibroma: A Rare Entity

Muhammad Tahir et al. Cureus. .

Abstract

Juvenile ossifying fibroma (JOF) is an unusual fibro-osseous lesion primarily occurring in children and young adolescents. Anatomically, this lesion could predominantly arise from the bilateral orbits, paranasal sinuses, maxilla, or mandible. Although it is a benign lesion of osseous origin, it is an aggressive variant of ossifying fibroma of the jaw. Due to the aggressive nature of this lesion and its high tendency for recurrence, early radiological detection and prompt surgical treatment are required. The histologic diagnosis of this entity is purely based on hematoxylin and eosin (H&E), but immunohistochemistry and molecular diagnostic studies can also be performed in challenging cases. A thorough histopathological examination of this lesion is recommended because it can easily be mistaken for another benign fibrosis lesion arising at the same anatomical location. Here, we report the case of a juvenile psammomatoid ossifying fibroma (JPOF) occurring in a 12-year-old boy. The tumor is arising at an extracranial location behind the left anterior cranial fossa.

Keywords: cemento ossifying fibroma; fibroma; juvenile ossifying fibroma; juvenile psammomatoid ossifying fibroma; ossifying fibroma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. MRI of the head and brain, coronal and sagittal views showing the left extracranial lesion (red arrows in Figures A and B). MRI of the head and brain in coronal and sagittal views after resection (red arrows in Figures C and D)
MRI: magnetic resonance imaging
Figure 2
Figure 2. Benign fibro-osseous proliferation (Figure A: 4x, Figure B: 10x). Fibroblastic stroma containing round mineralized ossified microscopic concretions resembling psammoma bodies (Figure C: 40x, Figure D: 60x).
Figure 3
Figure 3. Vimentin is diffusely positive in the stromal component (Figure A: 10x). Normal expression of cytoplasmic beta-catenin (Figure B: 10x) . Low Ki-67 proliferation index (Figure C: 10x). Negative staining for EMA (Figure D: 10x).
EMA: epithelial membrane antigen
See this image and copyright information in PMC

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