Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Aug 3:14:1195664.
doi: 10.3389/fneur.2023.1195664. eCollection 2023.

Neuroblastoma of the lumbosacral canal in an adult: a case report and literature review

Qingyu Jiang  1 , Haihao Gao  1 , Gan Gao  1 , Yang Li  2 , Haofeng Cheng  3 , Guoliang Shi  1 , Aijia Shang  4
Affiliations
Case Reports

Neuroblastoma of the lumbosacral canal in an adult: a case report and literature review

Qingyu Jiang et al. Front Neurol. .

Abstract

Neuroblastoma (NB) is a leading cause of death in children. It usually occurs in the adrenal gland and rarely in the spinal canal. Here, we report the case of a 48-year-old male patient with abnormal thickening of the cauda equina nerve as revealed by lumbosacral magnetic resonance imaging. The patient's main clinical manifestations were numbness and pain in both lower limbs. The patient underwent surgical treatment; however, intraoperatively, an unclear border was observed between the cauda equina nerve and the tumor; therefore, the tumor was not forcibly excised. The postoperative pathological results were reported as NB. The disease known as NB, which is extremely rare. We believe that a pathological biopsy is extremely vital for diagnosing NB, and aggressive post-operative radio-chemotherapy could potentially prolong the patient's survival time.

Keywords: lumbosacral canal; neuroblastoma; neurological deficits; surgery; tumor.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer LD declared a shared affiliation with the authors to the handling editor at the time of review.

Figures

Figure 1
Figure 1
Sagittal and axial MRI revealed that the cauda equina was thickened, and enhanced MRI revealed that the cauda equina was significantly enhanced (at the white arrow). MRI, magnetic resonance imaging.
Figure 2
Figure 2
PET/CT indicating that the cauda equina in the spinal canal is thickened. SUVmax (Standardized Uptake Value): 2.7. PET/CT, positron emission tomography/computed tomography.
Figure 3
Figure 3
(A) The cauda equina nerve is surrounded by tumors, yellow-white, soft, and rich in blood supply. (B) Blunt stripping of the tumor and cauda equina nerve. (C) Sufficient hemostasis after biopsy. (D) Suture of the dura mater.
Figure 4
Figure 4
(A) Hematoxylin–eosin stain (×400) shows tumor cell sheet distribution, moderate atypia, eosinophilic cytoplasm, oval cells, nuclear staining, some visible nucleoli, and no clear necrosis. (B) Ki67 immunohistochemical staining (×400) shows approximately 30% positive rate. (C) NF immunohistochemical staining (×400). (D) NFD Nestin immunohistochemical staining (×400) shows a partial positive rate.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet. (2007) 369:2106–20. doi: 10.1016/S0140-6736(07)60983-0 - DOI - PubMed
    1. Owens C, Irwin M. Neuroblastoma: the impact of biology and cooperation leading to personalized treatments. Crit Rev Clin Lab Sci. (2012) 49:85–115. doi: 10.3109/10408363.2012.683483, PMID: - DOI - PubMed
    1. Irwin MS, Park JR. Neuroblastoma: paradigm for precision medicine. Pediatr Clin N Am. (2015) 62:225–56. doi: 10.1016/j.pcl.2014.09.015, PMID: - DOI - PubMed
    1. de Camargo B, de Oliveira Ferreira JM, de Souza RR, Ferman S, de Oliveira SM, Pombo-de-Oliveira MS. Socioeconomic status and the incidence of non-central nervous system childhood embryonic tumours in Brazil. BMC Cancer. (2011) 11:160. doi: 10.1186/1471-2407-11-160 - DOI - PMC - PubMed
    1. Gaspar N, Hartmann O, Munzer C, Bergeron C, Millot F, Cousin-Lafay L, et al. . Neuroblastoma in adolescents. Cancer. (2003) 98:349–55. doi: 10.1002/cncr.11521, PMID: - DOI - PubMed

Publication types

LinkOut - more resources