KRAS^G12C mutation in metastatic colorectal cancer: a new target

Affiliations

¹ International Department, Gustave Roussy Cancer Campus, Villejuif, 94800, France.
² Department of Head & Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, 94800, France.

Editorial

Rebecca Ibrahim et al. Future Oncol. 2023 Aug.

. 2023 Aug;19(24):1641-1643.

doi: 10.2217/fon-2023-0223. Epub 2023 Aug 21.

¹ International Department, Gustave Roussy Cancer Campus, Villejuif, 94800, France.
² Department of Head & Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, 94800, France.

No abstract available

Keywords: KRASG12C mutation; RAS; adagrasib; colorectal cancer; sotorasib.

Comment on

KRAS^G12C-independent feedback activation of wild-type RAS constrains KRAS^G12C inhibitor efficacy.
Ryan MB, Coker O, Sorokin A, Fella K, Barnes H, Wong E, Kanikarla P, Gao F, Zhang Y, Zhou L, Kopetz S, Corcoran RB. Ryan MB, et al. Cell Rep. 2022 Jun 21;39(12):110993. doi: 10.1016/j.celrep.2022.110993. Cell Rep. 2022. PMID: 35732135 Free PMC article.