Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Sep;15(3):487-94.

Atopic dermatitis. A genetic-epidemiologic study in a population-based twin sample

F S Larsen, N V Holm, K Henningsen
  • PMID: 3760273

Atopic dermatitis. A genetic-epidemiologic study in a population-based twin sample

F S Larsen et al. J Am Acad Dermatol. 1986 Sep.

Abstract

Atopic dermatitis is a multifactorial disease that seems both to rise in frequency and to be dependent on a genetic predisposition. In order to clarify these issues we encircled a representative twin series with atopic dermatitis from a total twin population of 592 like-sexed twin pairs. We found that the cumulative incidence rate (0-7 years) of atopic dermatitis in Denmark has increased significantly from 0.03 for the birth cohort 1960-1964 to 0.10 for the birth cohort 1970-1974, that monozygotic twin pairs are more often concordant for atopic dermatitis than dizygotic twin pairs, that monozygotic twins run a risk of 0.86 of having atopic dermatitis if the twin partner has the disease, whereas the disease risk of 0.21 run by dizygotic partners does not differ from the frequency seen in ordinary brothers and sisters. The results indicate that genetic factors play a decisive role in the development of atopic dermatitis and that widespread environmental factors are operating in genetically susceptible individuals.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • The genetics of atopic dermatitis.
    Chien YH, Hwu WL, Chiang BL. Chien YH, et al. Clin Rev Allergy Immunol. 2007 Dec;33(3):178-90. doi: 10.1007/s12016-007-0041-8. Clin Rev Allergy Immunol. 2007. PMID: 18163224 Review.
  • Strategies for prevention.
    Vandenplas Y. Vandenplas Y. Clin Rev Allergy Immunol. 1995 Winter;13(4):361-71. doi: 10.1007/BF02801845. Clin Rev Allergy Immunol. 1995. PMID: 8680955 Review.
  • Twin Studies of Atopic Dermatitis: Interpretations and Applications in the Filaggrin Era.
    Elmose C, Thomsen SF. Elmose C, et al. J Allergy (Cairo). 2015;2015:902359. doi: 10.1155/2015/902359. Epub 2015 Sep 10. J Allergy (Cairo). 2015. PMID: 26448767 Free PMC article. Review.
  • European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
    Budu-Aggrey A, Kilanowski A, Sobczyk MK; 23andMe Research Team; Shringarpure SS, Mitchell R, Reis K, Reigo A; Estonian Biobank Research Team; Mägi R, Nelis M, Tanaka N, Brumpton BM, Thomas LF, Sole-Navais P, Flatley C, Espuela-Ortiz A, Herrera-Luis E, Lominchar JVT, Bork-Jensen J, Marenholz I, Arnau-Soler A, Jeong A, Fawcett KA, Baurecht H, Rodriguez E, Alves AC, Kumar A, Sleiman PM, Chang X, Medina-Gomez C, Hu C, Xu CJ, Qi C, El-Heis S, Titcombe P, Antoun E, Fadista J, Wang CA, Thiering E, Wu B, Kress S, Kothalawala DM, Kadalayil L, Duan J, Zhang H, Hadebe S, Hoffmann T, Jorgenson E, Choquet H, Risch N, Njølstad P, Andreassen OA, Johansson S, Almqvist C, Gong T, Ullemar V, Karlsson R, Magnusson PKE, Szwajda A, Burchard EG, Thyssen JP, Hansen T, Kårhus LL, Dantoft TM, Jeanrenaud ACSN, Ghauri A, Arnold A, Homuth G, Lau S, Nöthen MM, Hübner N, Imboden M, Visconti A, Falchi M, Bataille V, Hysi P, Ballardini N, Boomsma DI, Hottenga JJ, Müller-Nurasyid M, Ahluwalia TS, Stokholm J, Chawes B, Schoos AM, Esplugues A, Bustamante M, Raby B, Arshad S, German C, Esko T, Milani LA, Metspalu A, Terao C, Abuabara K, Løset M, Hveem K, Jacobsson B, Pino-Yanes M, Strachan DP, Grarup N, Linneberg A,… See abstract for full author list ➔ Budu-Aggrey A, et al. Nat Commun. 2023 Oct 4;14(1):6172. doi: 10.1038/s41467-023-41180-2. Nat Commun. 2023. PMID: 37794016 Free PMC article.
  • The epidemiology and experience of atopic eczema during childhood: a discussion paper on the implications of current knowledge for health care, public health policy and research.
    Fennessy M, Coupland S, Popay J, Naysmith K. Fennessy M, et al. J Epidemiol Community Health. 2000 Aug;54(8):581-9. doi: 10.1136/jech.54.8.581. J Epidemiol Community Health. 2000. PMID: 10890869 Free PMC article. Review.
See all "Cited by" articles

Publication types

LinkOut - more resources