Characterization of the novel HLA-A*33:246 allele using next-generation sequencing

Pascal Pedini^{1

2}, Beila Brami¹, Alexandre Walencik³, Coralie Frassati^{1

2}, Christophe Picard^{1

2}

Affiliations

¹ Immunogenetics Laboratory, Etablissement français du Sang PACA Corse, Marseille, France.
² ADES UMR, Aix Marseille University, Marseille, France.
³ Imunogenetics Laboratory, Etablissement français du Sang, Nantes, France.

Pascal Pedini et al. HLA. 2023 Nov.

. 2023 Nov;102(5):617-619.

doi: 10.1111/tan.15194. Epub 2023 Aug 21.

Pascal Pedini^{1

2}, Beila Brami¹, Alexandre Walencik³, Coralie Frassati^{1

2}, Christophe Picard^{1

2}

¹ Immunogenetics Laboratory, Etablissement français du Sang PACA Corse, Marseille, France.
² ADES UMR, Aix Marseille University, Marseille, France.
³ Imunogenetics Laboratory, Etablissement français du Sang, Nantes, France.

Abstract

HLA-A*33:246 differs from HLA-A*33:01:01:01 allele by one nucleotide substitution in codon 135 in exon 3.

Keywords: HLA-A*33:246; HLA; NGS; new methods; novel allele.

1. Alizadeh M, Picard C, Frassati C, et al. A new set of reagents and related software used for NGS based classical and non-classical HLA typing showing evidence for a greater HLA haplotype diversity. Hum Immunol. 2020;81(5):202-205. doi:10.1016/j.humimm.2020.02.003
1. Barker DJ, Maccari G, Georgiou X, et al. The IPD-IMGT/HLA database. Nucleic Acids Res. 2023;51(D1):D1053-D1060. doi:10.1093/nar/gkac1011
1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens. 2010;75(4):291-455. doi:10.1111/j.1399-0039.2010.01466.x