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Review

Nalmefene

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
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Review

Nalmefene

No authors listed.
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Excerpt

No information is available on the use of nalmefene in nursing mothers. If nalmefene is required by the mother for an opiate overdose, she should withhold nursing until the opiate is out of her system. Because nalmefene has some oral bioavailability, use in a nursing mother might cause abstinence symptoms in a breastfed infant who is opioid tolerant.

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References

    1. Kreek MJ, Schluger J, Borg L, et al. Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: Gender differences and implications for modulation of dopaminergic tone in the treatment of addictions. J Pharmacol Exp Ther 1999;288:260-9. - PubMed
    1. Bart G, Schluger JH, Borg L, et al. Nalmefene induced elevation in serum prolactin in normal human volunteers: Partial kappa opioid agonist activity? Neuropsychopharmacology 2005;30:2254-62. - PubMed

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