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Comment
. 2023 Oct;22(10):785.
doi: 10.1038/d41573-023-00137-2.

Targeting EMT in cancer through netrin-1

M Teresa Villanueva
Comment

Targeting EMT in cancer through netrin-1

M Teresa Villanueva. Nat Rev Drug Discov. 2023 Oct.
No abstract available

Keywords: Cancer; Drug discovery.

PubMed Disclaimer

Comment on

  • Pharmacological targeting of netrin-1 inhibits EMT in cancer.
    Lengrand J, Pastushenko I, Vanuytven S, Song Y, Venet D, Sarate RM, Bellina M, Moers V, Boinet A, Sifrim A, Rama N, Ducarouge B, Van Herck J, Dubois C, Scozzaro S, Lemaire S, Gieskes S, Bonni S, Collin A, Braissand N, Allard J, Zindy E, Decaestecker C, Sotiriou C, Salmon I, Mehlen P, Voet T, Bernet A, Blanpain C. Lengrand J, et al. Nature. 2023 Aug;620(7973):402-408. doi: 10.1038/s41586-023-06372-2. Epub 2023 Aug 2. Nature. 2023. PMID: 37532929 Free PMC article.
  • Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer.
    Cassier PA, Navaridas R, Bellina M, Rama N, Ducarouge B, Hernandez-Vargas H, Delord JP, Lengrand J, Paradisi A, Fattet L, Garin G, Gheit H, Dalban C, Pastushenko I, Neves D, Jelin R, Gadot N, Braissand N, Léon S, Degletagne C, Matias-Guiu X, Devouassoux-Shisheboran M, Mery-Lamarche E, Allard J, Zindy E, Decaestecker C, Salmon I, Perol D, Dolcet X, Ray-Coquard I, Blanpain C, Bernet A, Mehlen P. Cassier PA, et al. Nature. 2023 Aug;620(7973):409-416. doi: 10.1038/s41586-023-06367-z. Epub 2023 Aug 2. Nature. 2023. PMID: 37532934 Free PMC article. Clinical Trial.

References

    1. Lengrand, J. et al. Pharmacological targeting of netrin-1 inhibits EMT in cancer. Nature 620, 402–408 (2023) - PubMed - DOI
    1. Cassier, P. A. et al. Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer. Nature 620, 409–416 (2023) - PubMed - DOI - PMC

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