Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 28;7(3):51.
doi: 10.3390/vision7030051.

Combined Branch Retinal Artery and Central Retinal Vein Occlusion: A Systematic Review

Antonio Pinna  1   2 , Angelo Zinellu  3 , Rita Serra  3 , Giacomo Boscia  4 , Lorenza Ronchi  2 , Stefano Dore  1   2
Affiliations
Review

Combined Branch Retinal Artery and Central Retinal Vein Occlusion: A Systematic Review

Antonio Pinna et al. Vision (Basel). .

Abstract

We performed a systematic review and analyzed the current available data on branch retinal artery occlusion (BRAO) with simultaneous central retinal vein obstruction (CRVO), a rarely described occurrence. MEDLINE/PubMed and ISI Web of Sciences searches were performed according to MOOSE guidelines. Studies were considered eligible if they (1) described patients with simultaneous BRAO + CRVO and (2) had been published in peer-reviewed journals. We initially identified 239 records from databases. Ultimately, only 19 reports met the selection criteria. Twenty-nine patients (15 men, 14 women; mean age 43 ± 15 years) were analyzed. Seventeen (59%) patients presented vascular risk factors. Mean visual acuity at onset and final visual outcome were 20/83 and 20/45, respectively, an insignificant improvement. Vision improved in 48% of cases. A marked heterogeneity in treatment approach was found. Eight (28%) patients received no therapy, whereas for 21 (72%) a large variety of topical and/or systemic drugs was given. In the treated group, mean visual acuity at onset and final visual outcome were 20/90 and 20/44, respectively, a not statistically significant improvement. Results suggest that combined BRAO + CRVO occurs at a younger age than isolated BRAO or CRVO. At present, there is insufficient evidence to support any specific management to improve vision in simultaneous BRAO + CRVO.

Keywords: branch retinal artery obstruction; central retinal vein occlusion; combined; management; systematic review.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA 2020 flow diagram outlining the selection process for the inclusion of the studies in the systematic review [23].
See this image and copyright information in PMC

References

    1. Duker J.S., Cohen M.S., Brown G.C., Sergott R.C., McNamara J.A. Combined branch retinal artery and central retinal vein obstruction. Retina. 1990;10:105–112. doi: 10.1097/00006982-199004000-00003. - DOI - PubMed
    1. Tavola A., D’Angelo S.V., Bandello F., Brancato R., Parlavecchia M., Safa O., D’Angelo A. Central retinal vein and branch artery occlusion associated with inherited plasminogen deficiency and high lipoprotein(a) levels: A case report. Thromb. Res. 1995;80:327–331. doi: 10.1016/0049-3848(95)00183-R. - DOI - PubMed
    1. Singh A.J. Branch retinal artery obstruction with simultaneous central retinal vein occlusion. Eye. 2001;15:225–227. doi: 10.1038/eye.2001.66. - DOI - PubMed
    1. Rubio J.E., Jr., Charles S. Interferon-associated combined branch retinal artery and central retinal vein obstruction. Retina. 2003;23:546–548. doi: 10.1097/00006982-200308000-00019. - DOI - PubMed
    1. Özdek Ş., Yülek F., Gürelik G., Aydin B., Hasanreisoğlu B. Simultaneous central retinal vein and retinal artery branch occlusions in two patients with homocysteinaemia. Eye. 2004;18:942–945. doi: 10.1038/sj.eye.6701355. - DOI - PubMed

LinkOut - more resources