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Editorial
. 2023 Oct 1;208(7):750-752.
doi: 10.1164/rccm.202308-1373ED.

PRS-ing Forward to Identify Genetic Risk in Idiopathic Pulmonary Fibrosis

Timothy S Blackwell  1   2   3 , Gunnar Gudmundsson  4
Affiliations
Editorial

PRS-ing Forward to Identify Genetic Risk in Idiopathic Pulmonary Fibrosis

Timothy S Blackwell et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Comment on

  • A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities.
    Moll M, Peljto AL, Kim JS, Xu H, Debban CL, Chen X, Menon A, Putman RK, Ghosh AJ, Saferali A, Nishino M, Hatabu H, Hobbs BD, Hecker J, McDermott G, Sparks JA, Wain LV, Allen RJ, Tobin MD, Raby BA, Chun S, Silverman EK, Zamora AC, Ortega VE, Garcia CK, Barr RG, Bleecker ER, Meyers DA, Kaner RJ, Rich SS, Manichaikul A, Rotter JI, Dupuis J, O'Connor GT, Fingerlin TE, Hunninghake GM, Schwartz DA, Cho MH. Moll M, et al. Am J Respir Crit Care Med. 2023 Oct 1;208(7):791-801. doi: 10.1164/rccm.202212-2257OC. Am J Respir Crit Care Med. 2023. PMID: 37523715 Free PMC article.

References

    1. Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, et al. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet . 2013;45:613–620. - PMC - PubMed
    1. Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, et al. A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med . 2011;364:1503–1512. - PMC - PubMed
    1. Wu X, Li W, Luo Z, Chen Y. The minor T allele of the MUC5B promoter rs35705950 associated with susceptibility to idiopathic pulmonary fibrosis: a meta-analysis. Sci Rep . 2021;11:24007. - PMC - PubMed
    1. Allen RJ, Stockwell A, Oldham JM, Guillen-Guio B, Schwartz DA, Maher TM, et al. International IPF Genetics Consortium Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis. Thorax . 2022;77:829–833. - PMC - PubMed
    1. Cross B, Turner R, Pirmohamed M. Polygenic risk scores: an overview from bench to bedside for personalised medicine. Front Genet . 2022;13:1000667. - PMC - PubMed