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Comment
. 2023 Aug 21;33(16):R875-R878.
doi: 10.1016/j.cub.2023.06.084.

Immunology: NACHT domain proteins get a prokaryotic origin story

Nicole D Marino  1 , Igor E Brodsky  2
Affiliations
Free article
Comment

Immunology: NACHT domain proteins get a prokaryotic origin story

Nicole D Marino et al. Curr Biol. .
Free article

Abstract

The NACHT domain is found in eukaryotic pattern recognition receptors that promote anti-microbial defense, mediating their oligomerization into immune signaling complexes. Kibby et al. uncover a superfamily of prokaryotic NACHT-containing proteins and demonstrate that some members of this family mediate anti-phage defense.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Bacterial NLR-related proteins protect against phage.
    Kibby EM, Conte AN, Burroughs AM, Nagy TA, Vargas JA, Whalen LA, Aravind L, Whiteley AT. Kibby EM, et al. Cell. 2023 May 25;186(11):2410-2424.e18. doi: 10.1016/j.cell.2023.04.015. Epub 2023 May 8. Cell. 2023. PMID: 37160116 Free PMC article.

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