A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy

doi:10.1002/anie.202308513

. 2023 Oct 9;62(41):e202308513.

doi: 10.1002/anie.202308513. Epub 2023 Sep 4.

A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy

Hao Hu¹, Yang-Yang Zhang^{1

2}, He Ma¹, Yuchong Yang¹, Shan Mei¹, Jun Li^{1

2}, Jiang-Fei Xu¹, Xi Zhang¹

Affiliations

¹ Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Engineering Research Center of Advanced Rare-Earth Materials of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
² Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518005, China.

PMID: 37607898
DOI: 10.1002/anie.202308513

A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy

Hao Hu et al. Angew Chem Int Ed Engl. 2023.

. 2023 Oct 9;62(41):e202308513.

doi: 10.1002/anie.202308513. Epub 2023 Sep 4.

Authors

Hao Hu¹, Yang-Yang Zhang^{1

2}, He Ma¹, Yuchong Yang¹, Shan Mei¹, Jun Li^{1

2}, Jiang-Fei Xu¹, Xi Zhang¹

Affiliations

¹ Key Lab of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Engineering Research Center of Advanced Rare-Earth Materials of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
² Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518005, China.

PMID: 37607898
DOI: 10.1002/anie.202308513

Abstract

We report a supramolecular naphthalene diimide (NDI) radical anion with efficient NIR-II photothermal conversion for E. coli-responsive photothermal therapy. The supramolecular radical anion (NDI-2CB[7])⋅^- , which is obtained from the E. coli-induced in situ reduction of NDI-2CB[7] neutral complex, formed by the host-guest interaction between an NDI derivative and cucurbit[7]uril (CB[7]), exhibits unexpectedly strong NIR-II absorption and remarkable photothermal conversion capacity in aqueous solution. The NIR-II absorption is caused by the self-assembly of NDI radical anions to form supramolecular dimer radicals in aqueous solution, which is supported by theoretically predicted spectra. The (NDI-2CB[7])⋅^- demonstrates excellent NIR-II photothermal antimicrobial activity (>99 %). This work provides a new approach for constructing NIR-II photothermal agents and non-contact treatments for bacterial infections.

Keywords: Antibacterial; Host-Guest Systems; Photochemistry; Photothermal Therapy; Supramolecular Chemistry.

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References

1. S. He, J. Song, J. Qu, Z. Cheng, Chem. Soc. Rev. 2018, 47, 4258.
1. X. Huang, I. H. El-Sayed, W. Qian, M. A. El-Sayed, J. Am. Chem. Soc. 2006, 128, 2115.
1. E. Boisselier, D. Astruc, Chem. Soc. Rev. 2009, 38, 1759.
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1. S. Liu, Y. Li, R. T. K. Kwok, J. W. Y. Lam, B. Z. Tang, Chem. Sci. 2021, 12, 3427.

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[1] S. He, J. Song, J. Qu, Z. Cheng, Chem. Soc. Rev. 2018, 47, 4258.

[2] S. He, J. Song, J. Qu, Z. Cheng, Chem. Soc. Rev. 2018, 47, 4258.

[3] X. Huang, I. H. El-Sayed, W. Qian, M. A. El-Sayed, J. Am. Chem. Soc. 2006, 128, 2115.

[4] X. Huang, I. H. El-Sayed, W. Qian, M. A. El-Sayed, J. Am. Chem. Soc. 2006, 128, 2115.

[5] E. Boisselier, D. Astruc, Chem. Soc. Rev. 2009, 38, 1759.

[6] E. Boisselier, D. Astruc, Chem. Soc. Rev. 2009, 38, 1759.

[7] S. Wu, H. J. Butt, Adv. Mater. 2016, 28, 1208.

[8] S. Wu, H. J. Butt, Adv. Mater. 2016, 28, 1208.

[9] S. Liu, Y. Li, R. T. K. Kwok, J. W. Y. Lam, B. Z. Tang, Chem. Sci. 2021, 12, 3427.

[10] S. Liu, Y. Li, R. T. K. Kwok, J. W. Y. Lam, B. Z. Tang, Chem. Sci. 2021, 12, 3427.

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A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy

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A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy

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