Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 15;4(2 Suppl):e106(1-5).
doi: 10.1097/OI9.0000000000000106. eCollection 2021 Apr.

The induced membrane technique for bone defects: Basic science, clinical evidence, and technical tips

Graeme Hoit  1 , Michael S Kain  2 , Jeremy W Sparkman  3 , Brent L Norris  3 , Janet D Conway  4 , J Tracy Watson  5 , Paul Tornetta 3rd  2 , Aaron Nauth  1   6
Affiliations

The induced membrane technique for bone defects: Basic science, clinical evidence, and technical tips

Graeme Hoit et al. OTA Int. .

Abstract

The clinical management of large bone defects continues to be a difficult clinical problem to manage for treating surgeons. The induced membrane technique is a commonly employed strategy to manage these complex injuries and achieve bone union. Basic science and clinical evidence continue to expand to address questions related to the biology of the membrane and how interventions may impact clinical outcomes. In this review, we discuss the basic science and clinical evidence for the induced membrane technique as well as provide indications for the procedure and technical tips for performing the induced membrane technique.

Keywords: Masquelet technique; bone defects; induced membrane technique; orthopaedic trauma; surgical technique.

PubMed Disclaimer

References

    1. Masquelet AC, Fitoussi F, Begue T, et al. Reconstruction of the long bones by the induced membrane and spongy autograft. Ann Chir Plast Esthet. 2000;45:346–353. - PubMed
    1. Masquelet AC. Induced membrane technique: pearls and pitfalls. J Orthop Trauma. 2017;31 (suppl 5):S36–S38. - PubMed
    1. Gruber HE, Ode G, Hoelscher G, et al. Osteogenic, stem cell and molecular characterisation of the human induced membrane from extremity bone defects. Bone Joint Res. 2016;5:106–115. - PMC - PubMed
    1. Yee MA, Mead MP, Alford AI, et al. Scientific understanding of the induced membrane technique: current status and future directions. J Orthop Trauma. 2017;31 (suppl 5):S3–S8. - PubMed
    1. Christou C, Oliver RA, Yu Y, Walsh WR. The Masquelet technique for membrane induction and the healing of ovine critical sized segmental defects. PLoS One. 2014;9:e114122. - PMC - PubMed