This is a preprint.
Arbovirus surveillance in pregnant women in north-central Nigeria, 2019-2022
- PMID: 37609234
- PMCID: PMC10441490
- DOI: 10.1101/2023.08.04.23293671
Arbovirus surveillance in pregnant women in north-central Nigeria, 2019-2022
Update in
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Arbovirus surveillance in pregnant women in north-central Nigeria, 2019-2022.J Clin Virol. 2023 Dec;169:105616. doi: 10.1016/j.jcv.2023.105616. Epub 2023 Nov 3. J Clin Virol. 2023. PMID: 37944259 Free PMC article.
Abstract
The adverse impact of Zika (ZIKV), dengue (DENV), and chikungunya (CHIKV) virus infection in pregnancy has been recognized in Latin America and Asia but is not well studied in Africa. In Nigeria, we screened 1006 pregnant women for ZIKV, DENV and CHIKV IgM/IgG by rapid test (2019-2022). Women with acute infection were recruited for prospective study and infants were examined for any abnormalities from delivery through six months. A subset of rapid test-reactive samples were confirmed using virus-specific ELISAs and neutralization assays. Prevalence of acute infection (IgM+) was 3.8%, 9.9% and 11.8% for ZIKV, DENV and CHIKV, respectively; co-infections represented 24.5% of all infections. Prevalence in asymptomatic women was twice the level of symptomatic infection. We found a significant association between acute maternal ZIKV/DENV/CHIKV infection and any gross abnormal birth outcome (p=0.014). Further prospective studies will contribute to our understanding of the clinical significance of these endemic arboviruses in Africa.