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. 2023 Aug 21;13(3):e12280.
doi: 10.1002/pul2.12280. eCollection 2023 Jul.

Increased serum activin A level in congenital heart disease-associated pulmonary artery hypertension: A comparative study from the COHARD-PH registry

Muhammad R Hadwiono  1   2 , Anggoro B Hartopo  1 , Widya Wasityastuti  3 , Dyah W Anggrahini  1 , Gusty R T Ryanto  4 , Noriaki Emoto  4   5 , Lucia K Dinarti  1
Affiliations

Increased serum activin A level in congenital heart disease-associated pulmonary artery hypertension: A comparative study from the COHARD-PH registry

Muhammad R Hadwiono et al. Pulm Circ. .

Abstract

Activin A, a member of TGF-β superfamily, has been implicated in the pathogenesis of pulmonary artery hypertension (PAH). PAH due to congenital heart disease (CHD-PAH) is a major problem in developing countries. Activin A may have a role in PAH development and progression among uncorrected CHD. In this comparative study, serum activin A level was significantly increased in subjects with uncorrected CHD without the presence of PH and were more significantly risen in CHD-PAH, as compared to control. The utilization of serum activin A measurement seems promising to identify uncorrected CHD patients with PAH development and progression.

Keywords: NT‐pro BNP; biomarkers; congenital heart disease; endothelin 1.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The incremental increase of serum activin A level among subject groups (p value from the Student T test, analyzed between groups).
Figure 2
Figure 2
(a) Positive correlation between activin A and NT‐proBNP levels in subjects with congenital heart disease (CHD) (both CHD‐noPH and CHD‐PAH) (r = 0.876, p < 0.001). (b) Positive correlation between activin A and NT‐proBNP levels in subjects with CHD‐pulmonary artery hypertension (PAH) (r = 0.900, p < 0.001).
See this image and copyright information in PMC

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