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Observational Study
. 2023 Jul 31:2023:5562495.
doi: 10.1155/2023/5562495. eCollection 2023.

Epidemiology and Association Rules Analysis for Pulmonary Tuberculosis Cases with Extrapulmonary Tuberculosis from Age and Gender Perspective: A Large-Scale Retrospective Multicenter Observational Study in China

Wanli Kang  1 , Jiajia Yu  1 , Chen Liang  1 , Quanhong Wang  2 , Liang Li  1 , Jian Du  1 , Hongyan Chen  3 , Jianxiong Liu  4 , Jinshan Ma  5 , Mingwu Li  6 , Jingmin Qin  7 , Wei Shu  1 , Peilan Zong  8 , Yi Zhang  9 , Xiaofeng Yan  10 , Zhiyi Yang  11 , Zaoxian Mei  12 , Qunyi Deng  13 , Pu Wang  14 , Wenge Han  15 , Meiying Wu  16 , Ling Chen  17 , Xinguo Zhao  18 , Lei Tan  19 , Fujian Li  20 , Chao Zheng  21 , Hongwei Liu  3 , Xinjie Li  4 , Ertai A  5 , Yingrong Du  6 , Fenglin Liu  7 , Wenyu Cui  9 , Song Yang  10 , Xiaohong Chen  11 , Junfeng Han  12 , Qingyao Xie  13 , Yanmei Feng  14 , Wenyu Liu  15 , Peijun Tang  16 , Jianyong Zhang  17 , Jian Zheng  18 , Dawei Chen  20 , Xiangyang Yao  21 , Tong Ren  3 , Yan Li  4 , Yuanyuan Li  5 , Lei Wu  6 , Qiang Song  7 , Mei Yang  2 , Jian Zhang  9 , Yuanyuan Liu  12 , Shuliang Guo  14 , Kun Yan  15 , Xinghua Shen  16 , Dan Lei  17 , Yanli Zhang  20 , Youcai Li  1 , Yongkang Dong  2 , Shenjie Tang  1
Affiliations
Observational Study

Epidemiology and Association Rules Analysis for Pulmonary Tuberculosis Cases with Extrapulmonary Tuberculosis from Age and Gender Perspective: A Large-Scale Retrospective Multicenter Observational Study in China

Wanli Kang et al. Int J Clin Pract. .

Abstract

Background: Tuberculosis (TB), a multisystemic disease with protean presentation, remains a major global health problem. Although concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) cases are commonly observed clinically, knowledge regarding concurrent PTB-EPTB is limited. Here, a large-scale multicenter observational study conducted in China aimed to study the epidemiology of concurrent PTB-EPTB cases by diagnostically defining TB types and then implementing association rules analysis.

Methods: The retrospective study was conducted at 21 hospitals in 15 provinces in China and included all inpatients with confirmed TB diagnoses admitted from Jan 2011 to Dec 2017. Association rules analysis was conducted for cases with concurrent PTB and various types of EPTB using the Apriori algorithm.

Results: Evaluation of 438,979TB inpatients indicated PTB was the most commonly diagnosed (82.05%) followed by tuberculous pleurisy (23.62%). Concurrent PTB-EPTB was found in 129,422 cases (29.48%) of which tuberculous pleurisy was the most common concurrent EPTB type observed. The multivariable logistic regression models demonstrated that odds ratios of concurrent PTB-EPTB cases varied by gender and age group. For PTB cases with concurrent EPTB, the strongest association was found between PTB and concurrent bronchial tuberculosis (lift = 1.09). For EPTB cases with concurrent PTB, the strongest association was found between pharyngeal/laryngeal tuberculosis and concurrent PTB (lift = 1.11). Confidence and lift values of concurrent PTB-EPTB cases varied with gender and age.

Conclusions: Numerous concurrent PTB-EPTB case types were observed, with confidence and lift values varying with gender and age. Clinicians should screen for concurrent PTB-EPTB in order to improve treatment outcomes.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

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