Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Aug 22:167:D7268.

[Urinary tract infection caused by Candida while using an SGLT-2 inhibitor]

[Article in Dutch]
Anna M Zeelenberg  1   2 , Gerard J van der Wielen  1 , Edith D Beishuizen  3 , David J Hetem  4
Affiliations
  • PMID: 37609918
Case Reports

[Urinary tract infection caused by Candida while using an SGLT-2 inhibitor]

[Article in Dutch]
Anna M Zeelenberg et al. Ned Tijdschr Geneeskd. .

Abstract

Background: Sodium glucose transporter 2 (SGLT-2) inhibitors are a relatively new group of antidiabetic drugs. The renal glucose reabsorption is blocked resulting in higher glucose levels in the urine (glucosuria). Recently studies are being conducted into the medications nephrological and cardiovascular potential. As a result, we may expect that SGLT-2 inhibitors will be more and more frequently prescribed. Thus, physicians of any specialty may come into contact with patients that are using this drug.

Case description: We describe a case of a male patient who developed a urinary tract infection with Candida glabrata while using a SGLT-2 inhibitor. After discontinuing the SGLT-2 inhibitor, the infection subsided.

Conclusion: Urinary tract infections from Candida are rarely seen in healthy individuals. Glucosuria is a known risk factor for fungal genital infections. More research is needed to determine whether SGLT-2 inhibitors increase the risk of fungal urinary tract infections.

PubMed Disclaimer