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Editorial
. 2023 Oct 1;208(7):746-748.
doi: 10.1164/rccm.202308-1417ED.

Oxygen Targets and the Future of Critical Care Clinical Research

Stephanie C DeMasi  1 , Wesley H Self  2   3 , Matthew W Semler  2   4
Affiliations
Editorial

Oxygen Targets and the Future of Critical Care Clinical Research

Stephanie C DeMasi et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
How research on oxygenation targets may inform the historical and future paradigms of critical care clinical research.
See this image and copyright information in PMC

Comment on

  • Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial.
    van der Wal LI, Grim CCA, Del Prado MR, van Westerloo DJ, Boerma EC, Rijnhart-de Jong HG, Reidinga AC, Loef BG, van der Heiden PLJ, Sigtermans MJ, Paulus F, Cornet AD, Loconte M, Schoonderbeek FJ, de Keizer NF, Bakhshi-Raiez F, Le Cessie S, Serpa Neto A, Pelosi P, Schultz MJ, Helmerhorst HJF, de Jonge E; ICONIC investigators. van der Wal LI, et al. Am J Respir Crit Care Med. 2023 Oct 1;208(7):770-779. doi: 10.1164/rccm.202303-0560OC. Am J Respir Crit Care Med. 2023. PMID: 37552556 Free PMC article. Clinical Trial.

References

    1. van der Wal LI, Grim CCA, Del Prado MR, van Westerloo DJ, Boerma EC, Rijnhart-de Jong HG, et al. ICONIC investigators Conservative versus liberal oxygenation targets in intensive care unit patients (ICONIC): a randomized clinical trial. Am J Respir Crit Care Med . 2023;208:770–779. - PMC - PubMed
    1. Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, Eastwood G, et al. ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group Conservative oxygen therapy during mechanical ventilation in the ICU. N Engl J Med . 2020;382:989–998. - PubMed
    1. Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA . 2016;316:1583–1589. - PubMed
    1. Schmidt H, Kjaergaard J, Hassager C, Mølstrøm S, Grand J, Borregaard B, et al. Oxygen targets in comatose survivors of cardiac arrest. N Engl J Med . 2022;387:1467–1476. - PubMed
    1. de Jonge E, Peelen L, Keijzers PJ, Joore H, de Lange D, van der Voort PHJ, et al. Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care . 2008;12:R156. - PMC - PubMed