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. 2023 Oct 1;45(7):e892-e898.
doi: 10.1097/MPH.0000000000002746. Epub 2023 Aug 23.

Implementing a Disease-specific Multidisciplinary Team and Order Set for Hemophagocytic Lymphohistiocytosis in a Pediatric Hospital

Meaghan Rousset  1 , Kaci Orr  2 , Evelyn Gartstein  3 , Aly Anthony  4 , Steven Brady  5 , Ana Rios  6 , Ricardo Guirola  7 , Maria Perez  7 , Gretchen Eames  4 , Richard Howrey  4 , Heidi Trinkman  4 , Natalia Chaimowitz  8 , Maranda Diaz  4 , Anish Ray  4
Affiliations

Implementing a Disease-specific Multidisciplinary Team and Order Set for Hemophagocytic Lymphohistiocytosis in a Pediatric Hospital

Meaghan Rousset et al. J Pediatr Hematol Oncol. .

Abstract

Objective: To improve outcomes of hemophagocytic lymphohistiocytosis (HLH), prompt recognition and treatment are necessary. A HLH multidisciplinary team was implemented at our institution, and we established an electronic order set to foster uniformity in the diagnostic approach. The goal of this study is to capture the impact of this diagnostic tool.

Methods: This is a retrospective study analyzing the utilization of a HLH-specific order set since time of implementation in June 2019 through December 2022. The trends in the utilization of the order set by providers were analyzed to evaluate the awareness and effectiveness of this tool.

Results: The order set was utilized 50 times, most commonly by hematology/oncology (50%) and infectious disease (26%). Utilization by providers on newly presenting patients included 4 times in the year 2019, 12 times in 2020, 16 times in 2021, and 18 times in 2022. Utilization was associated with the diagnosis of HLH in 9 patients (18%).

Conclusion: Implementation of an HLH-specific order set facilitated a systematic method to approach patients with suspected HLH. The utilization of the order set displayed an upward trend over time, indicating support of this tool among these providers. This tool can increase awareness and early identification of HLH.

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Conflict of interest statement

The authors declare no conflict of interest.

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