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. 1986 Aug;79(8):451-3.
doi: 10.1177/014107688607900806.

Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome

D J Evans, C W Burke

Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome

D J Evans et al. J R Soc Med. 1986 Aug.

Abstract

Forty-eight hirsute women were treated with spironolactone 100 mg twice daily for 3 to 12 months. Both facial and body hirsuties improved by 30-40%, and there was a threefold reduction in frequency of local treatments such as waxing or shaving. Plasma testosterone fell by 30%, though the improvement in hirsuties grading did not correlate with the fall in plasma testosterone. Six subjects discontinued treatment because of lack of effect, and 4 because of menstrual disturbance. Spironolactone was equally effective in the treatment of idiopathic hirsutism and of the polycystic ovary syndrome.

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