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. 2023 Nov;45(11):e13008.
doi: 10.1111/pim.13008. Epub 2023 Aug 23.

When the adrenals alert us to a systemic fungal disease

Daniel Alvarenga Fernandes  1 , Mariângela Ribeiro Resende  2 , Acsa Caroline Mesquita da Silva  2 , André Almeida Schenka  3 , Icléia Barreto  4 , Fabiano Reis  1
Affiliations

When the adrenals alert us to a systemic fungal disease

Daniel Alvarenga Fernandes et al. Parasite Immunol. 2023 Nov.

Abstract

We present a patient referred for investigation of adrenal insufficiency, confirmed due to disseminated paracoccidioidomycosis (PCM), with abdominal and central nervous system (CNS) involvement. Establishing the pathogenesis and immunological processes involved in chronic or latent infections by PCM has been challenging. Medical doctors caring for patients with immunodeficiencies should learn about these fungal infections to properly guide travel planning and have this possibility in the diagnostic arsenal when the patient returns from endemic areas. After 13 months of treatment, the patient showed good clinical evolution, and we repeated imaging exams, showing partial improvement of the preview lesions. Diagnosis and treatment can prevent catastrophic events.

Keywords: adrenal gland; adrenal gland diseases; adrenal insufficiency; disseminated fungal infection; fungal disease; paracoccidioidomycosis.

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References

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