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Case Reports
. 2023 Aug 22;2023(8):rjad433.
doi: 10.1093/jscr/rjad433. eCollection 2023 Aug.

Primary non leukemic myeloid sarcoma of the ureteral wall: a case report of a rare disease

Luigi Quaresima  1 , Giordano Polisini  2 , Daniela Fasanella  3 , Vanessa Cammarata  2 , Andrea Benedetto Galosi  2 , Willy Giannubilo  1
Affiliations
Case Reports

Primary non leukemic myeloid sarcoma of the ureteral wall: a case report of a rare disease

Luigi Quaresima et al. J Surg Case Rep. .

Abstract

Myeloid sarcoma (MS) is an extramedullary tumor mass causing proliferation of mature or immature blast cells of one or more myeloid lineages. Involvement of the genitourinary tract is rare. We present a case of MS of the ureteral wall. A 74-year-old man was evaluated for left hydronephrosis and ipsilateral low back pain. A computed tomography scan showed a nodular formation in the pelvic ureter. Urinary cytology revealed cellular atypia, so ureteroscopy was performed showing a distal ureteral mass. The histological examination of the biopsy revealed to be malignant neoplasm. The patient underwent left laparoscopic nephroureterectomy with bladder cuff excision. Microscopic histological examination revealed a tumor compatible with MS. A postoperative positron emission tomography revealed residual hypercaptation of the bladder, pelvic muscle and iliac nodes, so the patient started chemotherapy. A multidisciplinary approach was required, taking into account the patient's age, the already poor renal function and the location of the neoplasm.

Keywords: hydronephrosis; myeloid sarcoma; ureter; ureteral neoplasm; ureterectomy.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
(A, B) The retrograde pyelography, performer before ureteroscopy, showed a minus contrast at the level of the pelvic ureter with an upstream hydroureteronephrosis; (C) left ureteral mass seen at arterious CT-scan; (D) the arterious CT-scan showed a hydronephrosis with corticalization of the calyxes.
Figure 2
Figure 2
The immunohistochemical panel. The final histological examination showed microscopically a MS with the following immunohistochemistry: CD117 +, myeloperoxidase +, CD99 +, FLI1 +, CD34 +/−, TdT +/−.
See this image and copyright information in PMC

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