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. 2023 Nov;203(4):656-667.
doi: 10.1111/bjh.19062. Epub 2023 Aug 24.

Impairment of platelet function in both mild and severe COVID-19 patients

Mariangela Scavone  1 , Claudia Ghali  1 , Mariagrazia Calogiuri  1 , Matteo Sala  2 , Elena Bossi  1 , Tatiana Mencarini  3 , Silvia Bozzi  3 , Bianca Clerici  1 , Simone Birocchi  1 , Antonella Fioretti  1 , Valeria Bono  2 , Norma Maugeri  4 , Giulia Marchetti  2 , Marco Cattaneo  1 , Gian Marco Podda  1
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Free article

Impairment of platelet function in both mild and severe COVID-19 patients

Mariangela Scavone et al. Br J Haematol. 2023 Nov.
Free article

Abstract

Abnormalities of platelet function were reported in patients with severe COVID-19 (severe-C), but few data are available in patients with mild COVID-19 (mild-C) and after COVID-19 recovery. The aim of this study was to investigate platelet parameters in mild-C patients (n = 51), with no evidence of pneumonia, and severe-C patients (n = 49), during the acute phase and after recovery, compared to 43 healthy controls. Both mild-C and severe-C patients displayed increased circulating activated platelets, low δ-granule content (ADP, serotonin), impaired platelet activation by collagen (light transmission aggregometry) and impaired platelet thrombus formation on collagen-coated surfaces under controlled flow conditions (300/s shear rate). The observed abnormalities were more marked in severe-C patients than in mild-C patients. Overall, 61% (30/49) of mild-C and 73% (33/45) of severe-C patients displayed at least one abnormal platelet parameter. In a subgroup of just 13 patients who showed no persisting signs/symptoms of COVID-19 and were re-evaluated at least 1 month after recovery, 11 of the 13 subjects exhibited normalization of platelet parameters. In conclusion, mild abnormalities of platelet parameters were present not only in severe-C but also, albeit to a lesser extent, in mild-C patients during the acute phase of COVID-19 and normalized in most tested patients after clinical recovery.

Keywords: COVID-19; platelet; platelet aggregation; platelet δ-granules; thrombus formation.

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References

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