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. 2023 Aug 24;22(1):77.
doi: 10.1186/s12941-023-00625-8.

Secondary bacterial infections & extensively drug-resistant bacteria among COVID-19 hospitalized patients at the University Hospital in Kraków

A Pałka  1 , A Kujawska  1 , D A Hareza  2 , M Gajda  3   4 , Jerzy Wordliczek  5 , E Jachowicz-Matczak  3 , I Owsianka  4 , B Żółtowska  1 , A Chmielarczyk  3 , D Romaniszyn  3 , Gregorczyk-Maga I  6 , J Wójkowska-Mach  7
Affiliations

Secondary bacterial infections & extensively drug-resistant bacteria among COVID-19 hospitalized patients at the University Hospital in Kraków

A Pałka et al. Ann Clin Microbiol Antimicrob. .

Abstract

Introduction: Healthcare-associated infections (HAI) and bacterial antimicrobial resistance posed a therapeutic risk during the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to analyze the HAIs in COVID-19 patients in the Intensive Care Unit (ICU) and non-ICU at the University Hospital in Krakow (UHK) with an emphasis on the susceptibility of the most frequently isolated pathogens and the prevalence of extensively drug resistant (XDR) microorganisms.

Methods: This laboratory-based study was carried out at the University Hospital in Krakow in the ICU and non-ICUs dedicated to COVID-19 patients between May 2021 and January 2022. All isolates of Klebsiella pneumoniae were analyzed using PFGE protocol.

Results: 292 independent HAI cases were identified, with the predominance of urinary tract infections (UTI), especially in the non-ICU setting. The most common ICU syndrome was pneumonia (PNA). The prevalence of XDR organisms was 22.6% in the ICU and 14.8% in non-ICUs among all isolates. The incidence of carbapenem-resistant Enterobacteriaceae infection was 24.8 cases per 10,000 hospitalizations and the carbapenem-resistant A. baumannii infection incidence was 208.8 cases per 10,000 hospitalizations. The prevalence of XDR strains was highest in Acinetobacter spp, in PNA cases. The PFGE typing demonstrated that almost all XDR strains varied widely from each other.

Conclusions: In this study, there was a high incidence of HAI in COVID-19 patients, especially when compared to Western Europe and the United States. Similarly, the prevalence of XDR microorganisms, especially XDR-A.baumannii, was also high. PFGE did not confirm the horizontal spread of any organism strains.

Keywords: Acinetobacter baumannii; Bloodstream infections (BSI); Extensively drug-resistant; HAI; Intensive care unit (ICU); Poland.

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Conflict of interest statement

The authors declare no competing interests.

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