A promising RNA nanotechnology in clinical therapeutics: a future perspective narrative review

doi:10.2144/fsoa-2023-0067

Review

. 2023 Jul 18;9(8):FSO883.

doi: 10.2144/fsoa-2023-0067. eCollection 2023 Sep.

A promising RNA nanotechnology in clinical therapeutics: a future perspective narrative review

Affiliations

¹ Pharmaceutical Division, Ministry of health & population, Faiyum, Egypt.
² Department of Veterinary Medicine, Faculty of Veterinary Science, University of Veterinary & Animal Sciences, Lahore Punjab, Pakistan.
³ Department of Botany, Faculty of Life Science, Women University Multan.
⁴ Faculty of Pharmacy, Ain Shams University, Cario, Egypt.
⁵ Department of Food Science & Human Nutrition, University of Veterinary & Animal Sciences Lahore Punjab Pakistan.
⁶ Microbiology & Immunology Department, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
⁷ Genetics & Genetic engineering Department, Faculty of Agriculture, Benha University.
⁸ Faculty of Dentistry, Sinai University, Arish Branch, North Sinai, Egypt.
⁹ Physical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Egypt.
¹⁰ Department of Biochemistry & Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt.
¹¹ Department of Biochemistry, Faculty of Pharmacy, Sinai University, Kantra Branch, Ismailia, Egypt.

PMID: 37621841
PMCID: PMC10445585
DOI: 10.2144/fsoa-2023-0067

Review

A promising RNA nanotechnology in clinical therapeutics: a future perspective narrative review

Mahmoud M Tolba et al. Future Sci OA. 2023.

. 2023 Jul 18;9(8):FSO883.

doi: 10.2144/fsoa-2023-0067. eCollection 2023 Sep.

Authors

Affiliations

¹ Pharmaceutical Division, Ministry of health & population, Faiyum, Egypt.
² Department of Veterinary Medicine, Faculty of Veterinary Science, University of Veterinary & Animal Sciences, Lahore Punjab, Pakistan.
³ Department of Botany, Faculty of Life Science, Women University Multan.
⁴ Faculty of Pharmacy, Ain Shams University, Cario, Egypt.
⁵ Department of Food Science & Human Nutrition, University of Veterinary & Animal Sciences Lahore Punjab Pakistan.
⁶ Microbiology & Immunology Department, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
⁷ Genetics & Genetic engineering Department, Faculty of Agriculture, Benha University.
⁸ Faculty of Dentistry, Sinai University, Arish Branch, North Sinai, Egypt.
⁹ Physical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Egypt.
¹⁰ Department of Biochemistry & Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt.
¹¹ Department of Biochemistry, Faculty of Pharmacy, Sinai University, Kantra Branch, Ismailia, Egypt.

PMID: 37621841
PMCID: PMC10445585
DOI: 10.2144/fsoa-2023-0067

Abstract

Nanotechnology is the use of materials that have unique nanoscale properties. In recent years, nanotechnologies have shown promising results for human health, especially in cancer treatment. The self-assembly characteristic of RNA is a powerful bottom-up approach to the design and creation of nanostructures through interdisciplinary biological, chemical and physical techniques. The use of RNA nanotechnology in therapeutics is about to be realized. This review discusses different kinds of nano-based drug delivery systems and their characteristic features.

Keywords: RNA nanotechnology; endosomal escape; endosomes; nanoparticles; physicochemical properties; ribose nucleic acid.

Plain language summary

A branch of nanotechnology called RNA nanotechnology involves designing, studying, and utilizing synthetic structures based on RNA. This review discusses different kinds of nano-based drug delivery systems and their characteristic features. It aims to provide an overview of nanoparticles as a delivery system for gene therapy to treat diseases such as cancer. In order to enhance nanoparticle efficacy, these systems should be designed with this in mind in order to develop and test delivery systems rationally and scientifically.

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Conflict of interest statement

Conflicts of interest disclosure The authors declare that there are no conflicts of interest present.

Figures

**Figure 1.. Types of nanomaterials and composites considered in this review and different types of nanoparticles divided into organic, polymeric, bio-based and inorganic categories.**
**(A)** Features and types of nanomaterials. **(B)** Classifications of nanoparticles based on composition.

**Figure 2.. The generation of nanotechnology in different stages with future perspective.**

**Figure 3.. Showing mechanisms of endosomal escape.**

See this image and copyright information in PMC

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References

1. Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio FJM. The history of nanoscience and nanotechnology: from chemical-physical applications to nanomedicine. Molecules 25(1), 112 (2020). - PMC - PubMed
1. Dubey A, Shetty A, Ravi G, Kiritkumar MC, Prabhu P, Hebbar S et al. Development and investigation of a novel solid self-nanoemulsifying system loaded with hydrochlorothiazide for the treatment of hypertension. International Journal of Pharmaceutical Investigation 8(2), 83–91 (2018).
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[1] Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio FJM. The history of nanoscience and nanotechnology: from chemical-physical applications to nanomedicine. Molecules 25(1), 112 (2020). - PMC - PubMed

[2] Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio FJM. The history of nanoscience and nanotechnology: from chemical-physical applications to nanomedicine. Molecules 25(1), 112 (2020). - PMC - PubMed

[3] Dubey A, Shetty A, Ravi G, Kiritkumar MC, Prabhu P, Hebbar S et al. Development and investigation of a novel solid self-nanoemulsifying system loaded with hydrochlorothiazide for the treatment of hypertension. International Journal of Pharmaceutical Investigation 8(2), 83–91 (2018).

[4] Dubey A, Shetty A, Ravi G, Kiritkumar MC, Prabhu P, Hebbar S et al. Development and investigation of a novel solid self-nanoemulsifying system loaded with hydrochlorothiazide for the treatment of hypertension. International Journal of Pharmaceutical Investigation 8(2), 83–91 (2018).

[5] García-Pinel B, Porras-Alcalá C, Ortega-Rodríguez A, Sarabia F, Prados J, Melguizo C et al. Lipid-based nanoparticles: application and recent advances in cancer treatment. Nanomaterials 9(4), 638 (2019). - PMC - PubMed

[6] García-Pinel B, Porras-Alcalá C, Ortega-Rodríguez A, Sarabia F, Prados J, Melguizo C et al. Lipid-based nanoparticles: application and recent advances in cancer treatment. Nanomaterials 9(4), 638 (2019). - PMC - PubMed

[7] Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y et al. Liposome: classification, preparation, and applications. Nanoscale Research Letters 8(1), 1–9 (2013). - PMC - PubMed

[8] Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y et al. Liposome: classification, preparation, and applications. Nanoscale Research Letters 8(1), 1–9 (2013). - PMC - PubMed

[9] Attama A, Schicke B, Paepenmüller T, Müller-Goymann C. Solid lipid nanodispersions containing mixed lipid core and a polar hetero-lipid: characterization. European Journal of Pharmaceutics and Biopharmaceutics 67(1), 48–57 (2007). - PubMed

[10] Attama A, Schicke B, Paepenmüller T, Müller-Goymann C. Solid lipid nanodispersions containing mixed lipid core and a polar hetero-lipid: characterization. European Journal of Pharmaceutics and Biopharmaceutics 67(1), 48–57 (2007). - PubMed

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A promising RNA nanotechnology in clinical therapeutics: a future perspective narrative review

Affiliations

A promising RNA nanotechnology in clinical therapeutics: a future perspective narrative review

Authors

Affiliations

Abstract

Plain language summary

Conflict of interest statement

Figures

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Cited by

References

Publication types

LinkOut - more resources

Full Text Sources