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. 2023 Aug;169(8):001383.
doi: 10.1099/mic.0.001383.

Microbe Profile: Ruminococcus gnavus: the yin and yang of human gut symbionts

Nathalie Juge  1
Affiliations

Microbe Profile: Ruminococcus gnavus: the yin and yang of human gut symbionts

Nathalie Juge. Microbiology (Reading). 2023 Aug.

Abstract

Ruminococcus gnavus is a human gut symbiont, part of the infant and adult gut microbiota and associated with intestinal and extra-intestinal disorders. R. gnavus mechanisms of adaptation to the gut are strain-specific and underpinned by the capacity of R. gnavus strains to utilize mucin and dietary glycans and produce bacteriocins and adhesins. Several potential mediators underpinning the association between R. gnavus strains and diseases have been identified, including the capacity to elicit a pro- or anti-inflammatory host response and modulate host metabolism, secondary bile acids and tryptophan metabolic pathways. Based on increasing evidence from metagenomics studies in humans and functional investigations in vitro and in mouse models, R. gnavus is emerging as a main player in influencing health and disease outcomes from infants to the elderly.

Keywords: Ruminococcus gnavus; gut adaptation; gut microbiota; host–microbe interaction; intestinal and extra-intestinal diseases; intestinal mucus; metabolites.

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Conflict of interest statement

The author declares that there are no conflicts of interest.

References

    1. Moore WEC, Johnson JL, Holdeman LV. Emendation of Bacteroidaceae and Butyrivibrio and descriptions of Desulfomonas gen. nov. and ten new species in the genera Desulfomonas, Butyrivibrio, Eubacterium, Clostridium, and Ruminococcus . Int J Syst Bacteriol. 1976;26:238–252. doi: 10.1099/00207713-26-2-238. - DOI
    1. Togo AH, Diop A, Bittar F, Maraninchi M, Valero R, et al. Description of Mediterraneibacter massiliensis, gen. nov., sp. nov., a new genus isolated from the gut microbiota of an obese patient and reclassification of Ruminococcus faecis, Ruminococcus lactaris, Ruminococcus torques, Ruminococcus gnavus and Clostridium glycyrrhizinilyticum as Mediterraneibacter faecis comb. nov., Mediterraneibacter lactaris comb. nov., Mediterraneibacter torques comb. nov., Mediterraneibacter gnavus comb. nov. and Mediterraneibacter glycyrrhizinilyticus comb. nov. Antonie van Leeuwenhoek. 2018;111:2107–2128. doi: 10.1007/s10482-018-1104-y. - DOI - PubMed
    1. Crost EH, Coletto E, Bell A, Juge N. Ruminococcus gnavus: friend or foe for human health. FEMS Microbiol Rev. 2023;47:fuad014. doi: 10.1093/femsre/fuad014. - DOI - PMC - PubMed
    1. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65. doi: 10.1038/nature08821. - DOI - PMC - PubMed
    1. Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, et al. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science. 2016;351 doi: 10.1126/science.aad3311. - DOI - PMC - PubMed

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