[Relation between the yield of chromosome aberrations and the dose during irradiation of human lymphocytes in vitro and in vivo]

Abstract

The paper is concerned with the counting of aberrant cells and chromosome aberrations in the 1st mitosis in PHA stimulated lymphocytes of the peripheral blood of healthy donors following gamma-beam irradiation in vitro at a dose of 1-5 Gy and in lymphocytes of the peripheral blood and bone marrow of patients with acute leukemia (in remission) after therapeutic whole-body gamma-beam irradiation at a dose of 1.5-5 Gy (doses to the "body center"). After irradiation in vitro and in vivo regression equations for each studied cytogenetic index (percentage of cells with dicentrics, the frequency of dicentrics and dicentrics + centric rings) were the same in form but differed in coefficients. The distribution of dicentrics by cells at all doses was in conformity with Poisson's law. It was shown that the radiosensitivity of the peripheral blood lymphocyte chromosomes in healthy donors and leukemic patients (in remission) was approximately the same.