Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug 15;14(8):425.
doi: 10.3390/jfb14080425.

Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity

Diba Grace Auliya  1 , Ulfa Fauziah  2 , Vira Fuji Arini  2 , Soni Setiadji  3 , Fitrilawati Fitrilawati  2 , Arief Sjamsulaksan Kartasasmita  4 , Risdiana Risdiana  2
Affiliations

Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity

Diba Grace Auliya et al. J Funct Biomater. .

Abstract

Polydimethylsiloxane (PDMS) is a substitute for vitreous humour in vitreoretinal surgery and is usually produced from octamethylcyclotetrasiloxane (D4). In Indonesia, both commercial PDMS and D4 are limited and expensive. Dichlorodimethylsilane (DCMS) can be an alternative to produce PDMS. DCMS is cheaper and easier to obtain than D4. However, more extra effort is needed in order to produce PDMS from DCMS. Therefore, this study aimed to produce PDMS from DCMS by varying the ratio of DCMS precursor to dichloromethane (DCM) solvent at ratios of 1:1 and 1:4 through the hydrolysis-condensation method under neutral conditions. The PDMS produced had medium- (2.06 Pa·s) and high viscosity (3.59 Pa·s), with densities ranging from 0.96 to 0.99 g/mL. The refractive index was 1.4034-1.4036 and surface tension was 21 × 10-3 N/m, while they were able to transmit ~100% visible light, which were similar values to the commercial PDMS characteristics. PDMS samples were characterized using IR and NMR spectroscopy, which confirmed they were of PDMS type. The most optimum DCMS:DCM ratio was 1:1 due to the medium-viscosity PDMS type that could be produced. The in vitro HET-CAM toxicity test showed that samples were non-irritant, similar to PDMS produced from D4. PDMS from DCMS was non-toxic and ready to be used as a vitreous humuor substitution.

Keywords: DCM; DCMS; PDMS; high viscosity; hydrolysis–condensation; in vitro toxicity; medium viscosity; optimization; ratio.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The synthesis route of PDMS from DCMS.
Figure 2
Figure 2
The physical appearance of purified hydrolyzed gel (a) and PDMS sample (b).
Figure 3
Figure 3
Transmittance characterization results of (a) sample P-1 and (b) sample P-2.
Figure 4
Figure 4
PDMS functional group characterization results of (a) commercial low-viscosity PDMS, (b) sample P-1, (c) sample P-2, and (d) commercial high-viscosity PDMS.
Figure 5
Figure 5
Spectra of 1H-NMR (a) and 13C-NMR (b) of sample P-2.
Figure 6
Figure 6
Vessels of positive control (a), sample P-1 (b), sample P-2 (c), and negative control (d) at 0 s and 300 s, through the HET–CAM test.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Thacker M., Tseng C.-L., Lin F.-H. Substitutes and Colloidal System for Vitreous Replacement and Drug Delivery: Recent Progress and Future Prospective. Polymers. 2021;13:121. doi: 10.3390/polym13010121. - DOI - PMC - PubMed
    1. Alovisi C., Panico C., de Sanctis U., Eandi C.M. Vitreous Substitutes: Old and New Materials in Vitreoretinal Surgery. J. Ophthalmol. 2017;2017:3172138. doi: 10.1155/2017/3172138. - DOI - PMC - PubMed
    1. Baino F. The Use of Polymers in the Treatment of Retinal Detachment: Current Trends and Future Perspectives. Polymers. 2010;2:286–322. doi: 10.3390/polym2030286. - DOI
    1. Khurana A.K. Comprehensive Ophtalmology. 6rd, ed. Jaypee Brothers Medical Publishers (P) Ltd.; New Delhi, India: 2015.
    1. Barca F., Caporossi T., Rizzo S. Silicone Oil: Different Physical Proprieties and Clinical Applications. Bio. Med. Res. Int. 2014;2014:e502143. doi: 10.1155/2014/502143. - DOI - PMC - PubMed

LinkOut - more resources