Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 27;21(8):426.
doi: 10.3390/md21080426.

Marine Biomaterials: Hyaluronan

Rasha M Abdel-Rahman  1 , A M Abdel-Mohsen  1
Affiliations
Review

Marine Biomaterials: Hyaluronan

Rasha M Abdel-Rahman et al. Mar Drugs. .

Abstract

The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities in the field of biomaterials, providing sustainable and biocompatible alternatives to synthetic materials. Their unique properties and abundance in marine sources make them valuable resources for various biomedical and industrial applications. Due to high biocompatible features and participation in biological processes related to tissue healing, hyaluronic acid has become widely used in tissue engineering applications, especially in the wound healing process. The present review enlightens marine hyaluronan biomaterial providing its sources, extraction process, structures, chemical modifications, biological properties, and biocidal applications, especially for wound healing/dressing purposes. Meanwhile, we point out the future development of wound healing/dressing based on hyaluronan and its composites and potential challenges.

Keywords: characterization; composites; extraction process; hyaluronan; marine sources; wound healing applications.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of hyaluronic acid.
Figure 2
Figure 2
Different marine sources of hyaluronic acid.
Figure 3
Figure 3
Chemical modifications of hyaluronan.
Figure 4
Figure 4
Wound Healing Phases.
Figure 5
Figure 5
Preparation of hyaluronan fibers with silver nanoparticles. Photographs of native hyaluronan fibers (a), HA fibers with Ag0 (b), SEM of Ag0 @HA (c).
Figure 6
Figure 6
In-situ synthesis of zinc oxide nanoparticles using hyaluronan and polyvinyl alcohol.
Figure 7
Figure 7
Schematic diagram of HA-PEGSB-CMP hydrogel fabrication. (A): The synthesis of HA derivatives. (B): Chemical structure of CMP. (C): The synthetic way of PEGSB. (D): representation of HA-PEGSB-CMP hydrogel synthesis with dual crosslinking ways. (E): The application diagram of the hydrogels treating infected motion wound and promoting wound healing Reproduced with permission from ref. [77].
Figure 8
Figure 8
Macroscopic evaluation of wound healing in the defected skin of rats. Photographs of wounds at different day treatment (a), Description of the wound healing process (b); Wound closure percentage (c) (** p < 0.01, *** p < 0.001). Reproduced with permission from ref. [153].
Figure 9
Figure 9
Microstructure of the silk fibroin/hyaluronan 3D scaffolds. Different MW HA: (a) pure SF; (b) HA 0.6 × 106 Da; (c) HA 1.6 × 106 Da; (d) HA 2.6 × 106 Da. Reproduced with permission from ref. [163].
See this image and copyright information in PMC

References

    1. Khrunyk Y., Lach S., Petrenko I., Ehrlich H. Progress in Modern Marine Biomaterials Research. Mar. Drugs. 2020;18:589. doi: 10.3390/md18120589. - DOI - PMC - PubMed
    1. Abdel-Mohsen A.M., Jancar J., Abdel-Rahman R.M., Vojtek L., Hyršl P., Dušková M., Nejezchlebová H. A novel in situ Silver/hyaluronan bio-nanocomposite fabrics for wound and chronic ulcer dressing: In vitro and in vivo evaluations. Int. J. Pharm. 2017;520:241–253. doi: 10.1016/j.ijpharm.2017.02.003. - DOI - PubMed
    1. Zhang H., Wu X., Quan L., Ao Q. Characteristics of Marine Biomaterials and Their Applications in Biomedicine. Mar. Drugs. 2022;20:372. doi: 10.3390/md20060372. - DOI - PMC - PubMed
    1. Kim K.S., Kim S., Beack S., Yang J.-A., Yun S.H., Hahn S.K. In vivo real-time confocal microscopy for target-specific delivery of hyaluronic acid-quantum dot conjugates. Nanomed. Nanotechnol. Biol. Med. 2012;8:1070–1073. doi: 10.1016/j.nano.2012.05.014. - DOI - PubMed
    1. Thomas R.G., Moon M.J., Lee H., Sasikala A.R.K., Kim C.S., Park I.-K., Jeong Y.Y. Hyaluronic acid conjugated superparamagnetic iron oxide nanoparticle for cancer diagnosis and hyperthermia therapy. Carbohydr. Polym. 2015;131:439–446. doi: 10.1016/j.carbpol.2015.06.010. - DOI - PubMed

LinkOut - more resources