Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul 27;13(8):701.
doi: 10.3390/membranes13080701.

Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva

Anna V Parshina  1 , Ekaterina Yu Safronova  2 , Svetlana A Novikova  2 , Nastasia Stretton  2 , Anastasia S Yelnikova  1 , Timur R Zhuchkov  1 , Olga V Bobreshova  1 , Andrey B Yaroslavtsev  2
Affiliations

Perfluorosulfonic Acid Membranes with Short and Long Side Chains and Their Use in Sensors for the Determination of Markers of Viral Diseases in Saliva

Anna V Parshina et al. Membranes (Basel). .

Abstract

The development of accessible express methods to determine markers of viral diseases in saliva is currently an actual problem. Novel cross-sensitive sensors based on Donnan potential with bio-comparable perfluorosulfonic acid membranes for the determination of salivary viral markers (N-acetyl-L-methionine, L-carnitine, and L-lysine) were proposed. Membranes were formed by casting from dispersions of Nafion or Aquivion in N-methyl-2-pyrollidone or in a mixture of isopropyl alcohol and water. The influence of the polymer equivalent weight and the nature of dispersing liquid on water uptake, ion conductivity, and slope of Donnan potential for the membranes in H+ and Na+ form was investigated. The varying of the sorption and transport properties of perfluorosulfonic acid membranes provided a change in the distribution of the sensor sensitivity to N-acetyl-L-methionine, L-carnitine, and L-lysine ions, which was necessary for multisensory system development. The simultaneous determination of three analytes, and the group analysis of them in artificial saliva solutions, was performed. The errors of N-acetyl-L-methionine and L-carnitine determination were 4-12 and 3-11%, respectively. The determination of L-lysine was complicated by its interaction with Ca2+ ions. The error of the group analysis was no greater than 9%. The reverse character of the viral markers' sorption by the membranes provided long-term sensor operation.

Keywords: Aquivion; Donnan potential; Nafion; PFSA membrane; ion transport; low-molecular-weight marker; potentiometric multisensory system; saliva; viral disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Dependence of the DP-sensor response on the negative decimal logarithm of the total concentration of AM+/±, CT+/±, and LS+ ions (pY) in artificial saliva solutions diluted 10 and 100 times.
Figure 2
Figure 2
Sensitivity of DP-sensor based on Nafion 212 and Aquivion 87 membranes to ions of viral markers (AM+/±, CT+/±, or LS+) and H3O+ in artificial saliva solutions.
Figure 3
Figure 3
Sensitivity of DP-sensors based on PFSA membranes to ions of AM+/±, CT+/±, LS+, and H3O+ upon their simultaneous presence in artificial saliva solutions.
Figure 4
Figure 4
Simultaneous determination of AM+/±, CT+/±, and LS+ ions in artificial saliva solutions with concentrations ranged from 1.0 × 10−5 to 1.0 × 10−3 M.
Figure 5
Figure 5
Group analysis of viral markers in artificial saliva solutions using DP-sensors based on commercial membranes (a) and membranes obtained by casting procedure (b).
Figure 6
Figure 6
Fragments of FTIR spectra of Nafion 212 membrane after sorption of viral markers from their individual solutions (a) and after their desorption (b).
See this image and copyright information in PMC

References

    1. Issaoui M., Jellali S., Zorpas A.A., Dutournie P. Membrane Technology for Sustainable Water Resources Management: Challenges and Future Projections. Sustain. Chem. Pharm. 2022;25:100590. doi: 10.1016/j.scp.2021.100590. - DOI
    1. Goh P.S., Wong K.C., Ismail A.F. Membrane Technology: A Versatile Tool for Saline Wastewater Treatment and Resource Recovery. Desalination. 2022;521:115377. doi: 10.1016/j.desal.2021.115377. - DOI
    1. Bu Y., Hu Q., Bao T., Xie X., Wang S. Recent Advances in Cell Membrane-Coated Technology for Drug Discovery from Natural Products. TrAC Trends Anal. Chem. 2022;151:116601. doi: 10.1016/j.trac.2022.116601. - DOI
    1. Gkotsis P., Kougias P., Mitrakas M., Zouboulis A. Biogas Upgrading Technologies—Recent Advances in Membrane-Based Processes. Int. J. Hydrogen Energy. 2023;48:3965–3993. doi: 10.1016/j.ijhydene.2022.10.228. - DOI
    1. Morker H., Saini B., Dey A. Role of Membrane Technology in Food Industry Effluent Treatment. Mater. Today Proc. 2023;77:314–321. doi: 10.1016/j.matpr.2022.11.406. - DOI

LinkOut - more resources