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Review
. 2023 Aug 16;11(8):706.
doi: 10.3390/toxics11080706.

Rapid Assessment of Ocular Toxicity from Environmental Contaminants Based on Visually Mediated Zebrafish Behavior Studies

Jia Yi  1 , Yilei Ma  1 , Jiahui Ma  1 , Haiyang Yu  1 , Kun Zhang  2 , Libo Jin  3 , Qinsi Yang  4 , Da Sun  1   3 , Dejun Wu  5
Affiliations
Review

Rapid Assessment of Ocular Toxicity from Environmental Contaminants Based on Visually Mediated Zebrafish Behavior Studies

Jia Yi et al. Toxics. .

Abstract

The presence of contaminants in the environment has increased in recent years, and studies have demonstrated that these contaminants have the ability to penetrate the blood-retinal barrier and directly affect the visual systems of organisms. Zebrafish are recognized as an ideal model for human eye diseases due to their anatomical and functional similarities to the human eye, making them an efficient and versatile organism for studying ocular toxicity caused by environmental contaminants in the field of environmental toxicology. Meanwhile, zebrafish exhibit a diverse repertoire of visually mediated behaviors, and their visual system undergoes complex changes in behavioral responses when exposed to environmental contaminants, enabling rapid assessment of the ocular toxicity induced by such pollutants. Therefore, this review aimed to highlight the effectiveness of zebrafish as a model for examining the effects of environmental contaminants on ocular development. Special attention is given to the visually mediated behavior of zebrafish, which allows for a rapid assessment of ocular toxicity resulting from exposure to environmental contaminants. Additionally, the potential mechanisms by which environmental contaminants may induce ocular toxicity are briefly outlined.

Keywords: Zebrafish; behavior; environmental contaminants; ocular toxicity; rapid assessment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Assessing the ocular toxicity of environmental contaminants through visually mediated zebrafish behavioral studies. (Brominated flame retardants, BFRs; Microplastics, MPs; Pharmaceutical and personal care products, PPCPs; Endocrine disrupting chemicals, EDCs).
Figure 2
Figure 2
Structural similarities between the human and zebrafish retina.
Figure 3
Figure 3
Visually mediated behavioral paradigm in zebrafish.
Figure 4
Figure 4
Potential mechanisms of eye damage from environmental contaminants in zebrafish.
See this image and copyright information in PMC

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